© 1990 S. Karger AG. Basel 0020-5915/90/0922-0138 S 2.75/0

Int Arch Allergy Appl Immunol 1990;92:138-142

Bronchial Responsiveness to Mite Allergen in Atopic Dermatitis without Asthma M. Dohia, H. Okudaira3, H. Sugiyama3, K. Tsurumachib, M. Suko3, T. Nakagawa3, Y. Morita3, K. Ito3, H. Nakayamah, T. Miyamoto3 a Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, and h Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan

I

Abstract. Eight patients with atopic dermatitis (AD) without a history of asthmatic episodes and 8 patients with mite-allergic bronchial asthma (BA) were subjected to bronchial inhalation challenge with a nonspecific stimulus (acetylcholine) and an immunologically specific stimulus (house dust mite allergen). AD patients had a significantly greater concentration of IgE (p 20,000 4,000 9,400 700 7,500 1,550

90.6 1.3

4,716

87.5 61.9 87.3 85.4 66.2 61.1 45.1 67.2

235 156 240 235 1,200 3,900 313 3,900

1,818 6,520 4,200 4,920 20,570 12,000 10,800 47,300

175.0 159.0 110.8 64.8 637.0 300.0 820.0 12.0

3.18 3.44 4.29 4.28 4.28 2.56 2.68 3.35

13,516 5,257

284.8 102.8

3.51 0.25

324 289 100 886 1,280 339 550 271

38.0 1.6 14.3 69.0 180.0 44.4 44.0 32.0

3.44 1.18 1.72 1.88 2.39 3.90 1.88 4.53

505** 138

52.9* 19.5

PC20AChb pg/ml

2.62 0.42

98 4.3

86 36 79 80 76 92 98 106 82 7.5

70.2 5.4

574*

PRU = Pharmacia rast units. * p