Bronchioloalveolar Carcinoma with Renal and Hepatic Metastases in a Degu (Octodon degus) Author(s): Wayne I. Anderson,Howard Steinberg, and John M. King Source: Journal of Wildlife Diseases, 26(1):129-131. Published By: Wildlife Disease Association DOI: http://dx.doi.org/10.7589/0090-3558-26.1.129 URL: http://www.bioone.org/doi/full/10.7589/0090-3558-26.1.129

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Journal

Bronchioloalveolar Carcinoma Degu (Octodon degus) Wayne

I. Anderson,

of Veterinary

with

Steinberg,

Cornell

A primary

ABSTRACT:

cinoma

Howard

Medicine,

renal

and

with Renal

and John

University,

Ithaca,

M. King,

New

York

bronchioloalveolar

car-

hepatic

was

metastases

in a mature male degu (Octodon dewas found dead in a zoological exhibit (Buffalo Zoological Gardens, Buffalo, New York, USA). Grossly, a discrete 0.5 cm diameter nodule was seen in the lung. Smaller, but similar

that

nodules

were

kidneys.

present

Histologically,

infiltrating nar evident.

Similar

cells

were

medulla,

present and

FIGURE

chitecture forming

1. by

a

and

the nest

occasional

acini

colum-

cortex

present

of

degu

(Octodon

Limited

degus)

information

on

State

College

lesions a

in the

reticulum

is a rodent

degu

listed

cell

sarcoma

can be parks.

neoplastic

and within

pulmonary

York

in a

South America. It in many zoological

ders in this species has been review article documenting

disor-

published. spontaneous

seven

A

neoplasms, of

a

cervical

ar-

population

of neoplastic

in

Bar

a degu.

New

was

neoplastic

renal

was

effacement

infiltrating

an

invasion

1990, pp. 129-131 Association 1990

Disease

Metastases

of Pathology,

indigenous to found on exhibit

effaced

of

26(1),

USA

The

and of

partially

sheets

within small

Diffuse an

sheets

Vascular

nests

liver

to low

cells

architecture.

the

and

of cuboidal

epithelial

pulmonary

in

nests

population

neoplastic

cells

scattered

and Hepatic

Department

14853,

Diseases, © Wildlife

the hepatic parenchyma. This is the first record of this neoplasm in a degu. Key words: Bronchioloalveolar carcinoma, renal, hepatic metastases, degu, Octodon degus, case report, pathology, neoplasia.

diagnosed gus)

of Wildlife

=

2.

FIGURE

75

showing

zm.

within 129

Detail

histological the

pulmonary

photomicrograph appearance parenchyma.

of of

Figure

neoplastic Bar

=

1 cells

25

sm.

130

JOURNAL

3.

FIGURE

filtrating =

OF WILDLIFE

the

Sheets renal

DISEASES,

and

nests

cortical

VOL

26, NO.

of neoplastic

interstitium

cells

in a degu.

1, JANUARY

inBar

lymph abdominal

node,

cinomas metastases), ,

a splenic lipoma, two

(one

with and

1980).

monary

In

two this

renal and hepatomas

an car-

pulmonary (Murphy

The occurrence

chioloalveolar carcinoma hepatic metastases.

text, a focal pulchange also was present report deof a primary bronwith

renal

and

A mature, male degu on exhibit at the Buffalo Zoological Gardens (Buffalo, New York 14214, USA), with no significant previous medical history, was found dead. A necropsy revealed the presence cm diameter, irregularly-shaped, white nodule within the pulmonary chyma.

Similar

nodules

ranging

of a 0.5 tan and parenfrom

cells

Detail

from

of

photomicrograph

Figure

liver, kidneys and buffered formalin

3. Bar

spleen and

0.1

to 0.25 cm in size were scattered within the kidneys and liver. Other gross lesions were not detected. Tissue samples of lung,

stained

with

hematoxylin

Histologically,

the

chyma was effaced sheets of an infiltrating columnar to cuboidal basophilic cytoplasm tinct cell boundaries.

of

25

rieo-

zm

were fixed in 10% submitted for his-

topatho!ogica! evaluation. routinely processed, sectioned

same

adenomatous

characterized. scribes the

hemangioma, hepatocellular

4.

FIGURE

plastic

75zm.

et al.

1990

Samples were at 4 jsm and and

eosin.

pulmonary

paren-

by

nests and small population of low epithelia! cells with and generally indisNuclei were round

and hyperchromatic. uncommon. Nests

of

Mitotic figures were epithe!ial cells oc-

casionally formed acini (Figs. 1, 2). Aggregates of similar cells were present within !umina of multiple bronchioles, and vascular

invasion

multifoca! in the

necrosis neoplastic

bronchioloalveolar Within the

was

evident.

and infiltrate.

was with-

A diagnosis

carcinoma parenchyma

There

hemorrhage

of

was renal

of made. cortex

SHORT

and

medulla,

alescing

nests

there

were

and

sheets

multifocal

to co-

of a similar

pop-

ulation of infiltrating neoplastic epithelial cells (Figs. 3, 4). A single small focus of neoplastic cells was present within a section of liver. The spleen normal. Representative this case are deposited

was histologically tissue blocks from in the Registry of

Comparative Pathology (Armed Forces Institute of Pathology, Washington, D.C. 20306, USA; Accession Number 2223076). To

our

represents

knowledge,

the

present

the first documented

bronchioloalveolar

carcinoma

Both

renal

and hepatic metastases in a degu. Spontaneous pulmonary neoplasms are uncommon in domestic rats and hamsters. Adenocarcinomas of alveolar origin have been described. In guinea pigs, lung tumors are

papillary

131

adenomas

and

adenocarcinomas have been documented. Various strains of mice have a high incidence alveolar

of pulmonary pneumocyte

neoplasia; being the

mon cell of origin. We express our

sincere

LITERATURE

J. C., T.

MURPHY,

Fox,

AND

sions

in the

of zoo

animals,

Smithsonian pp. Received

In R.

The

HEWES,

J. C. le-

comparative

J.Montali

Institution

and

Press,

pathology G. Migaki

Washington,

437-444. for

publication

23

of

Spontaneous

K. M. 1980.

SHALE\’.

degu.

to

Gardens case.

CITED

P. CORWELL,

M.

the type II most com-

appreciation

Allan W. Prowten, Zoological Buffalo, for submission of this

report

case of a with

common.

COMMUNICATIONS

June

1989.

(eds.). D.C.,