RESEARCH ARTICLE
Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation Zachary M. Earley1,2¤a, Suhail Akhtar1,3¤b, Stefan J. Green5, Ankur Naqib5, Omair Khan1, Abigail R. Cannon1,4, Adam M. Hammer1,2, Niya L. Morris1,2, Xiaoling Li1,3, Joshua M. Eberhardt3, Richard L Gamelli1,3, Richard H. Kennedy1, Mashkoor A. Choudhry1,2,3,4*
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OPEN ACCESS Citation: Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, et al. (2015) Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation. PLoS ONE 10(7): e0129996. doi:10.1371/journal.pone.0129996 Academic Editor: Raghavan Raju, Georgia Regents University, UNITED STATES Received: December 1, 2014 Accepted: May 15, 2015 Published: July 8, 2015 Copyright: © 2015 Earley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The amplicon sequence data from this study have been submitted to the NCBI Sequence Read Archive (SRA; http:// www.ncbi.nlm.nih.gov/Traces/sra/sra.cgi) under the BioProject (PRJNA273295) accession number SRP052710. Sequences derived from mice were uploaded as two independent FASTQ files representing forward and reverse reads from each sample. In sequences derived from human feces, sequence reads were imported into the software package CLC genomics workbench and mapped against the Hg19 human genome reference. Reads mapping to the human genome (
Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation Zachary M. Earley1,2¤a, Suhail Akhtar1,3¤b, Stefan J. Green5, Ankur Naqib5, Omair Khan1, Abigail R. Cannon1,4, Adam M. Hammer1,2, Niya L. Morris1,2, Xiaoling Li1,3, Joshua M. Eberhardt3, Richard L Gamelli1,3, Richard H. Kennedy1, Mashkoor A. Choudhry1,2,3,4*
a11111
OPEN ACCESS Citation: Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, et al. (2015) Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation. PLoS ONE 10(7): e0129996. doi:10.1371/journal.pone.0129996 Academic Editor: Raghavan Raju, Georgia Regents University, UNITED STATES Received: December 1, 2014 Accepted: May 15, 2015 Published: July 8, 2015 Copyright: © 2015 Earley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The amplicon sequence data from this study have been submitted to the NCBI Sequence Read Archive (SRA; http:// www.ncbi.nlm.nih.gov/Traces/sra/sra.cgi) under the BioProject (PRJNA273295) accession number SRP052710. Sequences derived from mice were uploaded as two independent FASTQ files representing forward and reverse reads from each sample. In sequences derived from human feces, sequence reads were imported into the software package CLC genomics workbench and mapped against the Hg19 human genome reference. Reads mapping to the human genome (
