Kathy
B Knight
and Robert
participated
supplementation signed to control pressure and ing the 20-wk had
hypertensive
to determine
the effects
serum total and supplementation lowering
effect
on diastolic
blood
of the study in the hypertensive control subjects’ mean serum
dietary
for systolic
KEY
calcium
pressure
J Clin Nuir
sure
and
and
hypertensive
ionic calcium were measured period. Calcium supplementation
intake
and
of the experwas observed
pressure
for diastolic
(r
Am
l992;55:891-5.
WORDS
motensive
Calcium,
pregnant
blood
women,
pressure,
hypertensive
pregnancy, pregnant
nor-
A total
Lafayette
pressure. blood
rats
epidemiologic
an inverse Calcium
women.
served that in calories, ofthc
in normal
Belizan
rates
tosis in the world. and nonpregnant higher
sponding
control
and
to have
reductions
Villar
pressure
blood
to decrease
and
hypertensive
Hamlin
(12) oha diet have
low one
hypertension-ges-
that both pregnant diets
readings
than
had did
significone-
women
hypertension (14,
supplemented
in systolic
of pregnancy.
in pregnant
their diet with calcium 1 5). Belizan et al (16) blood
However,
with pressure Richards
women
was
and found
other that
2.0 g Ca/d
tended
during
second
et al
the
( 1 7) found
no
in the concentrations ofserum ionic calcium in norchronically hypertensive, and pregnancy-induced
hypertensive
subjects.
Because performed
relatively few with hypertensive
examined
the effects
Am J C/in Nuir
clinical-intervention pregnant women,
ofsupplcmenting
1992;55:89l-5.
Printed
1.0 g Ca/d in USA.
Lee County
the human
their
trials have the present
been study
on blood
pres-
© 1992 American
Society
The
committees
Auburn
had
both
Subjects
the with
considered indications
hyof
was considered to be pregnancythat some of these subjects had
before
After
All
project
from
University.
pregnancy.
12 wk gestation and were primigravidas pressure
20 hy18-28 y at the
Mississippi.
consent.
subjects
and aged clinics
> 140/85 mm Hg were subjects had no previous
complications. blood
15 white)
Departments,
gave
and
hypertension
collection,
black,
Health and
of Mississippi
tered the study at (36 wk). All subjects
baseline
data
measurement, assigned dietary
Each
subject
was followed and suffered collection
and to either practices,
en-
until term no other
24-h
(blood diet
recall)
a control group, on a calcium-sup-
plemented group, which received two Os-Cal (Marion Laboratories, Kansas City, MO) 500-mg Ca tablcts/d for 20 wk. A tablet count was performed once per week to check for compliance. Physiological
and
biochemical
After 20 wk (32 sample was obtained by a registered Both
subjects. studies
(15
women (14 black, 6 white) the outpatient maternity
a blood pressure reading pertensive. Because the
medical
in normotensive
protocol
informed
from
University
values
methods
each subject was randomly which continued their usual
(9, 10) humans. been studied in
women with high in calcium and
sug-
and
reported
(1 1) and
pnoteinuria,
blood
by supplementing and vitamins pregnant
differences motensive,
intake
spontaneously
et al (13) also found rats on calcium-free
Belizan female
systolic
normal trimester
and
and Ethiopian vitamins but
ofedema,
In a few clinical reduced minerals
has been
(6)
Guatemalan protein, and
lowest
cantly
(4, 5) evidence
calcium
in normotensive (8) and hypertensive intake and blood pressure has also
Calcium
pregnant
and clinical between
supplementation
pressure (7) and
(1-3)
relationship
calcium
women.
of 30 normotensive
were
approval
serum
and experimental
undiagnosed
Recent
total pregnant
hypertension, the hypertension induced. However, it is possible
women
Introduction
gests
and
pertensive pregnant were selected from subjects
-0.386
=
pressure).
ionic
and
Subjects
Subjects oven
group only. The ionic calcium value
and blood
-0.359
dun-
pressure
decreased significantly (P < 0.05) over the course iment. A significant (P < 0.05) inverse relationship
between
pregnant of calcium
on blood pressure. Subjects were randomly asor supplemented groups (1000 mg Ca/d). Blood
a significant
the course hypertensive
and
in a study
and hypertensive
E Keith
Normotensive
ABSTRACT
women
on normotensive
wk gestation) another fasting venous from all subjects. Blood samples were
nurse
while
and
ending
beginning
data
all subjects blood
were samples
in a sitting were
drawn
blood taken
position. on sep-
arate days from when the blood pressure readings were taken to prevent anxiety-induced increases in blood pressures. Ionic calcium was measured by using an ion-specific electrode (Orion Research, Cambridge, MA) in serum obtained under an-
I
From
the Department
ofHome
Economics,
University
of Mississippi,
University MS. and the Department of Nutrition and Foods, Auburn University, Auburn, AL. 2 Address reprint requests to KB Knight, Department of Home Economics, University of Mississippi, University, MS 38677. Received May 24, 1991. Accepted for publication October 2, 1991. for Clinical
Nutrition
891
Downloaded from https://academic.oup.com/ajcn/article-abstract/55/4/891/4694400 by University of Rhode Island user on 06 December 2018
Calcium supplementation pregnant women1’2
KNIGHT
892 aerobic
conditions
duplicate
within
according
(by
to Teitz
serum
calcium
tometry to Teitz
using
vacuum
tubes);
2 h. Determination (18)
and
Scientific
Instruments,
Blood
pressure
readings study
directions.
were
by using
taken
once
CT)
Although supplementation was discontinued of pregnancy), blood pressure was measured 4 wk
until
at this blood
term
(36 wk)
to detect allowed
changes
time.
Subjects
pressure
was
measured.
All subjects
when
blood
pressure
was measured;
position
were
any
after 20 wk (32 wk for an additional that
a rest
could
period
before
maintained
made by the same registered nurse, who was rienced in the recording of blood pressure.
trained
between
surements
were
(P
their
Blood in Table
were and
data
pressure
At the
time
(midway was
taken
period.
for
sampling
a total
of three
content
and
at the
period),
recalls
of the
food-composition
Statistical
pen
diets
tables
end
and
deviations
between
change in these were performed
hypertensive
between
subjects. changes
ofinitial
and
B Knight
and Robert
participated
supplementation signed to control pressure and ing the 20-wk had
hypertensive
to determine
the effects
serum total and supplementation lowering
effect
on diastolic
blood
of the study in the hypertensive control subjects’ mean serum
dietary
for systolic
KEY
calcium
pressure
J Clin Nuir
sure
and
and
hypertensive
ionic calcium were measured period. Calcium supplementation
intake
and
of the experwas observed
pressure
for diastolic
(r
Am
l992;55:891-5.
WORDS
motensive
Calcium,
pregnant
blood
women,
pressure,
hypertensive
pregnancy, pregnant
nor-
A total
Lafayette
pressure. blood
rats
epidemiologic
an inverse Calcium
women.
served that in calories, ofthc
in normal
Belizan
rates
tosis in the world. and nonpregnant higher
sponding
control
and
to have
reductions
Villar
pressure
blood
to decrease
and
hypertensive
Hamlin
(12) oha diet have
low one
hypertension-ges-
that both pregnant diets
readings
than
had did
significone-
women
hypertension (14,
supplemented
in systolic
of pregnancy.
in pregnant
their diet with calcium 1 5). Belizan et al (16) blood
However,
with pressure Richards
women
was
and found
other that
2.0 g Ca/d
tended
during
second
et al
the
( 1 7) found
no
in the concentrations ofserum ionic calcium in norchronically hypertensive, and pregnancy-induced
hypertensive
subjects.
Because performed
relatively few with hypertensive
examined
the effects
Am J C/in Nuir
clinical-intervention pregnant women,
ofsupplcmenting
1992;55:89l-5.
Printed
1.0 g Ca/d in USA.
Lee County
the human
their
trials have the present
been study
on blood
pres-
© 1992 American
Society
The
committees
Auburn
had
both
Subjects
the with
considered indications
hyof
was considered to be pregnancythat some of these subjects had
before
After
All
project
from
University.
pregnancy.
12 wk gestation and were primigravidas pressure
20 hy18-28 y at the
Mississippi.
consent.
subjects
and aged clinics
> 140/85 mm Hg were subjects had no previous
complications. blood
15 white)
Departments,
gave
and
hypertension
collection,
black,
Health and
of Mississippi
tered the study at (36 wk). All subjects
baseline
data
measurement, assigned dietary
Each
subject
was followed and suffered collection
and to either practices,
en-
until term no other
24-h
(blood diet
recall)
a control group, on a calcium-sup-
plemented group, which received two Os-Cal (Marion Laboratories, Kansas City, MO) 500-mg Ca tablcts/d for 20 wk. A tablet count was performed once per week to check for compliance. Physiological
and
biochemical
After 20 wk (32 sample was obtained by a registered Both
subjects. studies
(15
women (14 black, 6 white) the outpatient maternity
a blood pressure reading pertensive. Because the
medical
in normotensive
protocol
informed
from
University
values
methods
each subject was randomly which continued their usual
(9, 10) humans. been studied in
women with high in calcium and
sug-
and
reported
(1 1) and
pnoteinuria,
blood
by supplementing and vitamins pregnant
differences motensive,
intake
spontaneously
et al (13) also found rats on calcium-free
Belizan female
systolic
normal trimester
and
and Ethiopian vitamins but
ofedema,
In a few clinical reduced minerals
has been
(6)
Guatemalan protein, and
lowest
cantly
(4, 5) evidence
calcium
in normotensive (8) and hypertensive intake and blood pressure has also
Calcium
pregnant
and clinical between
supplementation
pressure (7) and
(1-3)
relationship
calcium
women.
of 30 normotensive
were
approval
serum
and experimental
undiagnosed
Recent
total pregnant
hypertension, the hypertension induced. However, it is possible
women
Introduction
gests
and
pertensive pregnant were selected from subjects
-0.386
=
pressure).
ionic
and
Subjects
Subjects oven
group only. The ionic calcium value
and blood
-0.359
dun-
pressure
decreased significantly (P < 0.05) over the course iment. A significant (P < 0.05) inverse relationship
between
pregnant of calcium
on blood pressure. Subjects were randomly asor supplemented groups (1000 mg Ca/d). Blood
a significant
the course hypertensive
and
in a study
and hypertensive
E Keith
Normotensive
ABSTRACT
women
on normotensive
wk gestation) another fasting venous from all subjects. Blood samples were
nurse
while
and
ending
beginning
data
all subjects blood
were samples
in a sitting were
drawn
blood taken
position. on sep-
arate days from when the blood pressure readings were taken to prevent anxiety-induced increases in blood pressures. Ionic calcium was measured by using an ion-specific electrode (Orion Research, Cambridge, MA) in serum obtained under an-
I
From
the Department
ofHome
Economics,
University
of Mississippi,
University MS. and the Department of Nutrition and Foods, Auburn University, Auburn, AL. 2 Address reprint requests to KB Knight, Department of Home Economics, University of Mississippi, University, MS 38677. Received May 24, 1991. Accepted for publication October 2, 1991. for Clinical
Nutrition
891
Downloaded from https://academic.oup.com/ajcn/article-abstract/55/4/891/4694400 by University of Rhode Island user on 06 December 2018
Calcium supplementation pregnant women1’2
KNIGHT
892 aerobic
conditions
duplicate
within
according
(by
to Teitz
serum
calcium
tometry to Teitz
using
vacuum
tubes);
2 h. Determination (18)
and
Scientific
Instruments,
Blood
pressure
readings study
directions.
were
by using
taken
once
CT)
Although supplementation was discontinued of pregnancy), blood pressure was measured 4 wk
until
at this blood
term
(36 wk)
to detect allowed
changes
time.
Subjects
pressure
was
measured.
All subjects
when
blood
pressure
was measured;
position
were
any
after 20 wk (32 wk for an additional that
a rest
could
period
before
maintained
made by the same registered nurse, who was rienced in the recording of blood pressure.
trained
between
surements
were
(P
their
Blood in Table
were and
data
pressure
At the
time
(midway was
taken
period.
for
sampling
a total
of three
content
and
at the
period),
recalls
of the
food-composition
Statistical
pen
diets
tables
end
and
deviations
between
change in these were performed
hypertensive
between
subjects. changes
ofinitial
and
