Calorie restriction and iopanoic acid effects on thyroid hormone metabolism15

ABSTRACT thyroid

We hormone

metabolism.

alone

(T3)

during

men

iopanoic

concentration,

and

hor-

received

a

Dur-

or placebo

fashion.

decline

on

cab-

kcal/d.

acid

crossover

a 28.3%

L Leibel,

acid

severe

of thyroid

obese

received

produced

during

by 6 wk of600

in a double-blind

derfeeding(IOP) from baseline. 289%

morbidly

Rudolph

of iopanoic

men

regulation

followed

patients (UF)

iodothyronine

the nutrition Eight

periods

feeding

in obese

diet

underfeeding,

for 2-wk

the effects

measured

to study

weight-maintenance ing

Yang, Elio Presta,5 B Van ha/lie

metabolism

rie restriction mone

Mei-Uih Theodore

Under-

in the

iopanoic

serum

tri-

plus

un-

acid

produced a 49.5% decline in T3 concentration Serum reverse T3 concentrations increased lOP

compared

with

UF alone

(p

0.001).


30% over desirable body weight; 1959 Metropolitan Life Insurance Tables (14)] aged 22-45 y were chosen for this study. They were examined and were in good health, had no history of cardiac or pulmonary disease, were nonsmokers, and were not taking medication. All volunteers

From the Department

I

ofMedicine,

North Shore University

tal, Manhasset, NY; the Department of Medicine, Cornell Medical College, New York; the Obesity Research Center, Roosevelt Hospital Center, New York; and the Laboratory Behavior

and

Metabolism,

Presented

2

tion

for Clinical 3

Rockefeller

University,

New

Hospi-

University St Luke’s-

of Human

York.

in part at the National Meeting ofthe American Research, San Diego, May 1-4, 1987.

Federa-

Supported by NIH grants DK 26687, DK 33890, and GCRC RRand the Obesity Research Center. Address reprint requests to HL Katzeff, Department of Medicine,

00102 4

North Shore NY 11030. 5 Deceased.

University

ReceivedJuly Accepted for Clinical

300 Community

Drive,

Manhasset,

10, 1989.

for publication Nutrition

Hospital,

September

27, 1989.

263

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Harvey L Katzeff Jules Hirsch, and

264 were

admitted

Research sent

to the

Center obtained

was

the institutional During an ceived

Rockefeller

for the

in writing

45%

was

adjusted

lowed

every

by a 6-wk

unteers erals

in

allowances received

a 600-kcal/d

carbohydrate amounts

sufficient

(RDAs) either lOP

I 5). During (Telepaque,

York)

or placebo

fashion

interrupted

lop

was 500

days

2-14.

to

for 2-wk

periods

by a 2-wk

mg every Blood

for serum

and

rium dialysis formed using

±

0.06

0.57

±

0.09

1.65

±

0.24II

2.67

±

0.44

2.06

±

0.46

1 .58

±

0.4 1 t

fF4 (pmol/L) TSH(mU/L)

20.4 3.47±

±

3.6

±

4.3

±

7.4t

mm-

dietary

Diagnostics, ity

San 0.04

being

the

free

fraction

was

Juan

crossover dosage

of

mg/d

for

by 500

determinations

CA)

All serum

samples

ual were analyzed in a single assay. On day 10 of both the placebo ments

of both

rates

were

T4 and

performed

on

50

diotracer

injection

and

T4

1 .85 MBq

‘31I-labeled subject’s

mg

blood

catheter

and

with

catheter

specified

intervals

ofboth

ity

injected

Technical

1251

(> 99%)

the

were

eight

measureproduction

before

They the

via forearm,

an

indwelling

which

was

from

120 mm

and

ofspecific

by

the

Center.

T3 and

being

‘31I-labeled

method

by high-pressure

Before

were with two

injected

passed through a filter (0.22 m, MA). Three milliliters blood were

(1 8)

liquid prepared separate

kept

the inthen

at

placed MA).

the

Millipore withdrawn

on a minicobumn The minicolumn

T4 were and

purity

under culture

3.27±

33.5

0.53

t

different

from

baseline,

different

from

underfed,

NJ)

and

mc, Princeton,

(Sarsted

±20.0

6.54±

l.lltf

8.rT3,reverseT3;fl’3,freeT3;tT4,freeT4. < 0.02,

jp

the

I

< 0.02,