Journal of Surgical Oncology 2015;111:459–464
Can Chemoradiation Allow for Omission of Lateral Pelvic Node Dissection for Locally Advanced Rectal Cancer? MIN JU KIM, MD,1 TAE HYUN KIM, MD,1 DAE YONG KIM, MD,1 SUN YOUNG KIM, MD,1 JI YEON BAEK, MD,1 HEE JIN CHANG, MD,1 SUNG CHAN PARK, MD,1* JI WON PARK, MD,1,2 1 AND JAE HWAN OH, MD 1
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea 2 Department of Surgery, Seoul National University College of Medicine, Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea
Objectives: We evaluated the relationship between pretreatment clinical parameters and lateral pelvic node (LPN) recurrence in patients with rectal cancer treated with a combination of curative resection and chemoradiotherapy (CRT) and attempted to identify the patients who might benefit from LPN dissection. Methods: This study involved 900 patients between June 2001 and June 2009. Pretreatment clinical parameters including radiological size of LPN were analyzed to identify risk factors associated with long-term outcomes. Results: Locoregional recurrence developed in 65 patients (7.2%); 42 (64.6%) had LPN recurrence, 20 (47.6%) of which had no distant metastasis. Multivariate analysis showed that LPN short-axis diameter (
Can Chemoradiation Allow for Omission of Lateral Pelvic Node Dissection for Locally Advanced Rectal Cancer? MIN JU KIM, MD,1 TAE HYUN KIM, MD,1 DAE YONG KIM, MD,1 SUN YOUNG KIM, MD,1 JI YEON BAEK, MD,1 HEE JIN CHANG, MD,1 SUNG CHAN PARK, MD,1* JI WON PARK, MD,1,2 1 AND JAE HWAN OH, MD 1
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea 2 Department of Surgery, Seoul National University College of Medicine, Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea
Objectives: We evaluated the relationship between pretreatment clinical parameters and lateral pelvic node (LPN) recurrence in patients with rectal cancer treated with a combination of curative resection and chemoradiotherapy (CRT) and attempted to identify the patients who might benefit from LPN dissection. Methods: This study involved 900 patients between June 2001 and June 2009. Pretreatment clinical parameters including radiological size of LPN were analyzed to identify risk factors associated with long-term outcomes. Results: Locoregional recurrence developed in 65 patients (7.2%); 42 (64.6%) had LPN recurrence, 20 (47.6%) of which had no distant metastasis. Multivariate analysis showed that LPN short-axis diameter (
