Cancer Le;~iers, 5 (1978) 103--106
~) Elsevier[North-Holland ,~lcientificPvlbl~shersLtd.
103
C~RCINOGENICITY OF N-NITROSOEPHEDR~krE IN R A T S G. EI~ISNBRAND, R. PREU.~$MANNaad D. SCHMAHL German Cancer Resea~r h C~n~er, Institute ~f Toxicology and Chemotherapy, Im Neuen$leimer Feld 280 6900Heidelberg. G.F.R.
(Received 6 April 1978]~ (Reverendversion receb~ed23 ~ y 1978)
(Accepted 31May 1978)
SLWII~i~,Y N-Nitmsoephedrb~e was adminis~tered orally to 32 male Sprague--Dawley rats at doses o f 120 mg]kg body wt. ~Lwiceweekly. Of the ~;reated animals, 50% died ~p~th prene~plastic and mal~,rnant lesions mainly in the liver, lung and forestomaeh. The median time o f death o f tumor beam~g ~Lnimals was 522 days after the beginning o f the experhnent. The observation o f hyperke:ratosis, papillomas, and I squamous cell cm~inoma o f ~he forestomach suggests that the compound not only exhibits sy.,~temic effects but is probably also a weak local caminogE~.
n~rRODUCTmN The formation of carcinogenic N-nitrosocompotmds from non-carcinogenic prectu'sors in vitro and in rive has received increasing attantion. C]iasses of compounds investigated chemically '.~d in animal experiments include nitrosatedL de.,2vatives of drugs, pasticide~, and many other biologically :,:e~evant N-nit~satable compoundb [3 ]. Ephedrine is a common][y used drag taken either as a single compotmd or, more oI~en, in combination with other: substances. Its N-ni'~roso dev::va£ive has been Lested for careinogel~[city in new!born mice b,y ~he int:mperitonea]: rout.e [4] ; 3 d,~sas of 200 mg]kg body w t , given on clays 1, 4 and 7 ~ffter b~rLh, induc~.
~) Elsevier[North-Holland ,~lcientificPvlbl~shersLtd.
103
C~RCINOGENICITY OF N-NITROSOEPHEDR~krE IN R A T S G. EI~ISNBRAND, R. PREU.~$MANNaad D. SCHMAHL German Cancer Resea~r h C~n~er, Institute ~f Toxicology and Chemotherapy, Im Neuen$leimer Feld 280 6900Heidelberg. G.F.R.
(Received 6 April 1978]~ (Reverendversion receb~ed23 ~ y 1978)
(Accepted 31May 1978)
SLWII~i~,Y N-Nitmsoephedrb~e was adminis~tered orally to 32 male Sprague--Dawley rats at doses o f 120 mg]kg body wt. ~Lwiceweekly. Of the ~;reated animals, 50% died ~p~th prene~plastic and mal~,rnant lesions mainly in the liver, lung and forestomaeh. The median time o f death o f tumor beam~g ~Lnimals was 522 days after the beginning o f the experhnent. The observation o f hyperke:ratosis, papillomas, and I squamous cell cm~inoma o f ~he forestomach suggests that the compound not only exhibits sy.,~temic effects but is probably also a weak local caminogE~.
n~rRODUCTmN The formation of carcinogenic N-nitrosocompotmds from non-carcinogenic prectu'sors in vitro and in rive has received increasing attantion. C]iasses of compounds investigated chemically '.~d in animal experiments include nitrosatedL de.,2vatives of drugs, pasticide~, and many other biologically :,:e~evant N-nit~satable compoundb [3 ]. Ephedrine is a common][y used drag taken either as a single compotmd or, more oI~en, in combination with other: substances. Its N-ni'~roso dev::va£ive has been Lested for careinogel~[city in new!born mice b,y ~he int:mperitonea]: rout.e [4] ; 3 d,~sas of 200 mg]kg body w t , given on clays 1, 4 and 7 ~ffter b~rLh, induc~.
