Cells to Surgery Quiz
Cells to Surgery Quiz: October 2014 Leyre Falto-Aizpurua1, Robert D. Griffith1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e6. doi:10.1038/jid.2014.337
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. A 23-year-old man presents with a 1.1-cm lesion (see image above) that arose a few months ago on the central forehead. What would be the next step in management?
a. Surgical excision. b. Cryosurgery. c. Topical chemotherapy. d. Mohs micrographic surgery (MMS). e. Electrodesiccation and curettage (ED&C).
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. A year after the appropriate care was administered, the patient developed a 3-cm lesion on the back of his thigh. Histopathologic examination of the lesion showed basal cell carcinoma (BCC), sclerosing type, with perineural invasion and positive margins. The patient refuses surgery. An appropriate evaluation and genetic testing confirmed that the patient has neval basal cell carcinoma syndrome. Which of the following therapies would be most appropriate for this patient? a. Topical chemotherapy. b. Cryosurgery. c. Vismodegib. d. Electrodesiccation and curettage (ED&C). e. Radiation.
3. The patient did not respond to treatment. The hedgehog (Hh) pathway and other potential targeted genes associated with BCC tumor development are being studied to further elucidate the cases of resistance against Hh-inhibiting agents. Which of the following groups of cells has been proposed as a target of gene therapy to regulate the formation of BCC? a. Bulge hair follicle stem cells. b. Bone marrow–derived stem cells. c. Multipotent stem cells in follicles and the interfollicular epidermis. d. CD4+CD49fhighCD34intermediate Sca1+ cell population in the skin. e. All of the above.
TOPIC ARTICLE The questions refer to the following article: Uhmann A, Heß I, Frommhold A et al. (2014) DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptchflox/flox CD4Cre+/− mice. J Invest Dermatol 134:2620–9
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.337
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Cells to Surgery Quiz: October 2014 Leyre Falto-Aizpurua1, Robert D. Griffith1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e6. doi:10.1038/jid.2014.337
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. A 23-year-old man presents with a 1.1-cm lesion (see image above) that arose a few months ago on the central forehead. What would be the next step in management?
a. Surgical excision. b. Cryosurgery. c. Topical chemotherapy. d. Mohs micrographic surgery (MMS). e. Electrodesiccation and curettage (ED&C).
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. A year after the appropriate care was administered, the patient developed a 3-cm lesion on the back of his thigh. Histopathologic examination of the lesion showed basal cell carcinoma (BCC), sclerosing type, with perineural invasion and positive margins. The patient refuses surgery. An appropriate evaluation and genetic testing confirmed that the patient has neval basal cell carcinoma syndrome. Which of the following therapies would be most appropriate for this patient? a. Topical chemotherapy. b. Cryosurgery. c. Vismodegib. d. Electrodesiccation and curettage (ED&C). e. Radiation.
3. The patient did not respond to treatment. The hedgehog (Hh) pathway and other potential targeted genes associated with BCC tumor development are being studied to further elucidate the cases of resistance against Hh-inhibiting agents. Which of the following groups of cells has been proposed as a target of gene therapy to regulate the formation of BCC? a. Bulge hair follicle stem cells. b. Bone marrow–derived stem cells. c. Multipotent stem cells in follicles and the interfollicular epidermis. d. CD4+CD49fhighCD34intermediate Sca1+ cell population in the skin. e. All of the above.
TOPIC ARTICLE The questions refer to the following article: Uhmann A, Heß I, Frommhold A et al. (2014) DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptchflox/flox CD4Cre+/− mice. J Invest Dermatol 134:2620–9
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.337
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
