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Brain Research Bulletin, Vol. 27, pp. 247-249. 0 Pergamon Press pk. 1991. Printed in the U.S.A.

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Central ANP Attenuates Pressor Responses to Central AVP in WKY and SHR K. STEPNIAKOWSKI,* Department

A. BUDZIKOWSKI,

S. LON AND E. SZCZEPANSKA-SADOWSKA’

of Clinical and Applied Physiology and *Department of Hypertension Warsaw School of Medicine, 00-927 Warsaw, Poland

Received

29 April

and Angiology

199 I

STEPNIAKOWSKI, K., A. BUDZIKOWSKI, S. LON AND E. SZCZEPANSKA-SADOWSKA. Central ANP attenuates pressor responses to central AVP in WKY and SHR. BRAIN RES BULL 27(2) 247-249, 1991. -Blood pressure and heart rate responses to intracerebroventricular (ICV) injections of atria1 natriuretic peptide (ANP, 125 ng) arginine vasopressin (AVP, 10 ng), combination of ANP (125 ng) and AVP (10 ng) or artificial cerebrospinal fluid (acsf, 5 ~1) were compared in conscious normotensive (WKY) and spontaneously hypertensive (SHR) rats. In both strains, ICV injection of AVP elicited significant increase of mean blood pressure (MP) and heart rate (HR). Increase of MP but not of HR was significantly greater in SHR than in WKY @

Central ANP attenuates pressor responses to central AVP in WKY and SHR.

Blood pressure and heart rate responses to intracerebroventricular (ICV) injections of atrial natriuretic peptide (ANP, 125 ng) arginine vasopressin (...
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