Brain Research Bulletin, Vol. 27, pp. 247-249. 0 Pergamon Press pk. 1991. Printed in the U.S.A.
RAPID COMMUNICATION
Central ANP Attenuates Pressor Responses to Central AVP in WKY and SHR K. STEPNIAKOWSKI,* Department
A. BUDZIKOWSKI,
S. LON AND E. SZCZEPANSKA-SADOWSKA’
of Clinical and Applied Physiology and *Department of Hypertension Warsaw School of Medicine, 00-927 Warsaw, Poland
Received
29 April
and Angiology
199 I
STEPNIAKOWSKI, K., A. BUDZIKOWSKI, S. LON AND E. SZCZEPANSKA-SADOWSKA. Central ANP attenuates pressor responses to central AVP in WKY and SHR. BRAIN RES BULL 27(2) 247-249, 1991. -Blood pressure and heart rate responses to intracerebroventricular (ICV) injections of atria1 natriuretic peptide (ANP, 125 ng) arginine vasopressin (AVP, 10 ng), combination of ANP (125 ng) and AVP (10 ng) or artificial cerebrospinal fluid (acsf, 5 ~1) were compared in conscious normotensive (WKY) and spontaneously hypertensive (SHR) rats. In both strains, ICV injection of AVP elicited significant increase of mean blood pressure (MP) and heart rate (HR). Increase of MP but not of HR was significantly greater in SHR than in WKY @