Acta physiol. scand. 1977. 99. 313-322 From the Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
Changes in ATP and Cyclic Nucleotide Levels during Sympathetic Nerve Stimulation in Canine Subcutaneous Adipose Tissue in situl BY
BERTILB. FREDHOLM, ERIKBELFRAGE and ELEONORA BLASCHKE Received 30 August 1976
Abstract FREDHOLM, B. B., E. BELFRAGE and E. BLASCHKE. Changes in ATP and cyclic nucleotide h e l s in canine subcufaneous adipose tissue during sympathetic nerve stimulation. Acta physiol. scand. 1977. 99. 313-.322. Subcutaneous adipose tissue in fed, female dogs was isolated. Biopsies of the tissue (30-150 mg) were taken and rapidly frozen in liquid nitrogen before, during and after nerve stimulation ( 3 4 Hz). In unstimulated adipose tissue the levels of ATPl were 741-7 nmol/g, of cyclic AMP 90+ 12 pmol/g and of cyclic GMP 1 8 i 3 pmol/g (meankS.E.). During sympathetic nerve stirnulation the levels of ATP and cyclic GMP fell by 30 and 50% respectively (p
Changes in ATP and Cyclic Nucleotide Levels during Sympathetic Nerve Stimulation in Canine Subcutaneous Adipose Tissue in situl BY
BERTILB. FREDHOLM, ERIKBELFRAGE and ELEONORA BLASCHKE Received 30 August 1976
Abstract FREDHOLM, B. B., E. BELFRAGE and E. BLASCHKE. Changes in ATP and cyclic nucleotide h e l s in canine subcufaneous adipose tissue during sympathetic nerve stimulation. Acta physiol. scand. 1977. 99. 313-.322. Subcutaneous adipose tissue in fed, female dogs was isolated. Biopsies of the tissue (30-150 mg) were taken and rapidly frozen in liquid nitrogen before, during and after nerve stimulation ( 3 4 Hz). In unstimulated adipose tissue the levels of ATPl were 741-7 nmol/g, of cyclic AMP 90+ 12 pmol/g and of cyclic GMP 1 8 i 3 pmol/g (meankS.E.). During sympathetic nerve stirnulation the levels of ATP and cyclic GMP fell by 30 and 50% respectively (p
