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Changes in heart rate variability and QT variability during the first trimester of pregnancy

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Institute of Physics and Engineering in Medicine Physiol. Meas. 36 (2015) 531–545

Physiological Measurement doi:10.1088/0967-3334/36/3/531

Changes in heart rate variability and QT variability during the first trimester of pregnancy R E Carpenter1, L A D’Silva1, S J Emery2, O Uzun3, D Rassi4 and M J Lewis1 1

  College of Engineering, Swansea University, Swansea, UK   Department of Gynaecology, Singleton Hospital, Swansea, UK 3   Department of Paediatric Cardiology, University Hospital of Wales, Cardiff, UK 4   College of Health and Human Sciences, Swansea University, Swansea, UK 2

E-mail: [email protected] Received 24 September 2014, revised 12 January 2015 Accepted for publication 26 January 2015 Published 18 February 2015 Abstract

The risk of new-onset arrhythmia during pregnancy is high, presumably relating to changes in both haemodynamic and cardiac autonomic function. The ability to non-invasively assess an individual’s risk of developing arrhythmia during pregnancy would therefore be clinically significant. We aimed to quantify electrocardiographic temporal characteristics during the first trimester of pregnancy and to compare these with non-pregnant controls. Ninety-nine pregnant women and sixty-three non-pregnant women underwent non-invasive cardiovascular and haemodynamic assessment during a protocol consisting of various physiological states (postural manoeurvres, light exercise and metronomic breathing). Variables measured included stroke volume, cardiac output, heart rate, heart rate variability, QT and QT variability and QTVI (a measure of the variability of QT relative to that of RR). Heart rate (p 

Changes in heart rate variability and QT variability during the first trimester of pregnancy.

The risk of new-onset arrhythmia during pregnancy is high, presumably relating to changes in both haemodynamic and cardiac autonomic function. The abi...
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