Hindawi Publishing Corporation International Journal of Endocrinology Volume 2016, Article ID 1416503, 5 pages http://dx.doi.org/10.1155/2016/1416503
Clinical Study Changes in Testosterone Levels and Sex Hormone-Binding Globulin Levels in Extremely Obese Men after Bariatric Surgery Patchaya Boonchaya-anant,1,2,3 Nitchakarn Laichuthai,1,2,3 Preaw Suwannasrisuk,2,3,4 Natnicha Houngngam,1,2,3 Suthep Udomsawaengsup,5 and Thiti Snabboon1,2,3 1
Hormonal and Metabolic Disorders Research Unit, Excellence Center for Diabetes, Hormone, and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 2 Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 3 King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand 4 Department of Medicine, Faculty of Medicine, Naresuan University Hospital, Phitsanulok, Thailand 5 Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Correspondence should be addressed to Patchaya Boonchaya-anant; b [email protected] Received 17 May 2016; Revised 29 July 2016; Accepted 18 August 2016 Academic Editor: Mario Maggi Copyright © 2016 Patchaya Boonchaya-anant et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Obesity is a risk factor for hypogonadotropic hypogonadism in men. Weight loss has been shown to improve hypogonadism in obese men. This study evaluated the early changes in sex hormones profile after bariatric surgery. Methods. This is a prospective study including 29 morbidly obese men. Main outcomes were changes in serum levels of total testosterone (TT), free testosterone (cFT), SHBG, estradiol, adiponectin, and leptin at 1 and 6 months after surgery. Results. The mean age of patients was 31 ± 8 years and the mean BMI was 56.8 ± 11.7 kg/m2 . Fifteen patients underwent Roux-en-Y gastric bypass and 14 patients underwent sleeve gastrectomy. At baseline, 22 patients (75.9%) had either low TT levels (
Clinical Study Changes in Testosterone Levels and Sex Hormone-Binding Globulin Levels in Extremely Obese Men after Bariatric Surgery Patchaya Boonchaya-anant,1,2,3 Nitchakarn Laichuthai,1,2,3 Preaw Suwannasrisuk,2,3,4 Natnicha Houngngam,1,2,3 Suthep Udomsawaengsup,5 and Thiti Snabboon1,2,3 1
Hormonal and Metabolic Disorders Research Unit, Excellence Center for Diabetes, Hormone, and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 2 Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 3 King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand 4 Department of Medicine, Faculty of Medicine, Naresuan University Hospital, Phitsanulok, Thailand 5 Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Correspondence should be addressed to Patchaya Boonchaya-anant; b [email protected] Received 17 May 2016; Revised 29 July 2016; Accepted 18 August 2016 Academic Editor: Mario Maggi Copyright © 2016 Patchaya Boonchaya-anant et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Obesity is a risk factor for hypogonadotropic hypogonadism in men. Weight loss has been shown to improve hypogonadism in obese men. This study evaluated the early changes in sex hormones profile after bariatric surgery. Methods. This is a prospective study including 29 morbidly obese men. Main outcomes were changes in serum levels of total testosterone (TT), free testosterone (cFT), SHBG, estradiol, adiponectin, and leptin at 1 and 6 months after surgery. Results. The mean age of patients was 31 ± 8 years and the mean BMI was 56.8 ± 11.7 kg/m2 . Fifteen patients underwent Roux-en-Y gastric bypass and 14 patients underwent sleeve gastrectomy. At baseline, 22 patients (75.9%) had either low TT levels (
