Clin. Cardiol. 15, 80-86 (1992)

Changes of Diastolic Function Induced by Cigarette Smoking: An Echocardiographic Study in Patients with Coronary Artery Disease T. STORK, M.D., H. EICHSTADT, M.D., M. MOCKEL, M.D., R. BORTFELDT, M.D., R. MOLLER,M.SC.,* H.HOCHREIN, M.D.

University Hospital Rudolf Virchow, Department of Cardiology & Radiology, and *Institute for Medical'Statistics and Informatics, Free University of Berlin, Berlin, Federal Republic of Germany

Summary: In 28 chronic smokers (11 women, 17 men, 53 k 10 years old) with coronary artery disease (>75% stenosis),left ventricular (LV) relaxation and filling behavior was assessed before and after inhalation of 0.9 mg nicotine (1 cigarette) by echocardiography.The following acute nicotine-mediated changes were noted (one-sided Wilcoxon test): heart rate increased from 67 to 81 beatshin (p>.OOl); the early diastolic flow (E wave) integral decreased from 49 to 39 mm (p

Changes of diastolic function induced by cigarette smoking: an echocardiographic study in patients with coronary artery disease.

In 28 chronic smokers (11 women, 17 men, 53 +/- 10 years old) with coronary artery disease (greater than 75% stenosis), left ventricular (LV) relaxati...
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