PRENATAL DIAGNOSIS, VOL.
12,347-355 (1992)
CHORIONIC MOSAICISM: ASSOCIATION WITH FETAL LOSS BUT NOT WITH ADVERSE PERINATAL OUTCOME R. J. WAPNER', J. L. SIMPSON', M. S. GOLBUS3, J. M. ZACHARY4, D. H. LEDBETTER5, R. J. DESNICK6, S. E. FOWLER', L. G. JACKSON', H. LUBS', R. J. MAHONY', E. PERGAMENT" G. G. RHOADS",
J. D. SHULMANI2 AND F. DE LA CRUZ13 Jefferson Medical College of Thomas Jeflerson University, Philadelphia. PA; University of Tennessee, Memphis, TN; University of California. San Francisco, CA; 4George Washington University, Washington, DC; 'Baylor College of Medicine, Houston, TX; 6Mount Sinai School of Medicine, New York, N Y ; 'Henry Ford Hospital, Southfield. MI; 'University of Miami. Miami, FL; Yale University, New Haven, CT; "Northestern University Medical School, Chicago, IL; 'Robert Wood Johnson School of Medicine, New Brunswick. NJ; 12Genetics and IVFlnstitute. Fairfax. VA; "National Institute of Child Health and Development, Bethesda. M D . U.S.A.
SUMMARY Cytogenetic data from the United States NICHD collaborative study of chorionic villus sampling (CVS) were used to evaluate the clinical significance of chorionic mosaicism. The 10 754 patients with normal cytogenetic results were compared wtih 108 patients (1.0 per cent) with placental mosaicism and 181 patients (1.6 per cent) with pseudomosaicism. Of the pregnancies intended to continue, the pregnancy loss rate was significantlygreater in patients with placental mosaicism than in the cytogenetically normal cohort (8.6 vs. 3.4 per cent, p 27 weeks
12 (0.1%)
0 (0.0%)
1 (0.6%)
9944 (96.6%)
74 (9 1.4%)
165 (95.4%)
Livebirths
*Patients electively terminating the pregnancy are excluded from this analysis. p
12,347-355 (1992)
CHORIONIC MOSAICISM: ASSOCIATION WITH FETAL LOSS BUT NOT WITH ADVERSE PERINATAL OUTCOME R. J. WAPNER', J. L. SIMPSON', M. S. GOLBUS3, J. M. ZACHARY4, D. H. LEDBETTER5, R. J. DESNICK6, S. E. FOWLER', L. G. JACKSON', H. LUBS', R. J. MAHONY', E. PERGAMENT" G. G. RHOADS",
J. D. SHULMANI2 AND F. DE LA CRUZ13 Jefferson Medical College of Thomas Jeflerson University, Philadelphia. PA; University of Tennessee, Memphis, TN; University of California. San Francisco, CA; 4George Washington University, Washington, DC; 'Baylor College of Medicine, Houston, TX; 6Mount Sinai School of Medicine, New York, N Y ; 'Henry Ford Hospital, Southfield. MI; 'University of Miami. Miami, FL; Yale University, New Haven, CT; "Northestern University Medical School, Chicago, IL; 'Robert Wood Johnson School of Medicine, New Brunswick. NJ; 12Genetics and IVFlnstitute. Fairfax. VA; "National Institute of Child Health and Development, Bethesda. M D . U.S.A.
SUMMARY Cytogenetic data from the United States NICHD collaborative study of chorionic villus sampling (CVS) were used to evaluate the clinical significance of chorionic mosaicism. The 10 754 patients with normal cytogenetic results were compared wtih 108 patients (1.0 per cent) with placental mosaicism and 181 patients (1.6 per cent) with pseudomosaicism. Of the pregnancies intended to continue, the pregnancy loss rate was significantlygreater in patients with placental mosaicism than in the cytogenetically normal cohort (8.6 vs. 3.4 per cent, p 27 weeks
12 (0.1%)
0 (0.0%)
1 (0.6%)
9944 (96.6%)
74 (9 1.4%)
165 (95.4%)
Livebirths
*Patients electively terminating the pregnancy are excluded from this analysis. p
