Accepted Manuscript Choroidal Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Alexander K. Schuster, Philippe Steinmetz, Tessa M. Forster, Frank C. Schlichtenbrede, Björn C. Harder, Jost B. Jonas PII:
S0002-9394(14)00552-2
DOI:
10.1016/j.ajo.2014.09.008
Reference:
AJOPHT 9061
To appear in:
American Journal of Ophthalmology
Received Date: 20 May 2014 Revised Date:
3 September 2014
Accepted Date: 4 September 2014
Please cite this article as: Schuster AK, Steinmetz P, Forster TM, Schlichtenbrede FC, Harder BC, Jonas JB, Choroidal Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy, American Journal of Ophthalmology (2014), doi: 10.1016/j.ajo.2014.09.008. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Abstract Purpose:
To examine choroidal thickness in non-arteritic anterior ischemic optic neuropathy
(AION). Design:
Retrospective case control study
Methods: Setting: Eye Clinic, University Medical Center Mannheim, Germany. The study group consisted of patients with non-arteritic AION, and the
RI PT
Study Population:
control group consisted of individuals with a normal fundus. Observation:
Choroidal thickness was measured by enhanced depth imaging of
spectral-domain optical coherence tomography. Main Outcome Measure: Results:
Choroidal thickness.
The study group consisted of 20 patients: 11 patients with acute non-arteritic AION
previously non-arteritic AION in the contralateral eye. patients (58 eyes).
SC
and an unaffected contralateral eye, and 9 patients with acute unilateral non-arteritic AION and The control group consisted of 58
In multivariate analysis, thinner subfoveal choroidal thickness (SFCT)
M AN U
was associated with the diagnosis of non-arteritic AION (P=0.001; regression coefficient B: -55.1), after adjusting age (P0.20)
(Table 1).
A similar result was obtained for the subgroup of patients with acute unilateral
RI PT
eye.
non-arteritic AION and previous non-arteritic AION in the contralateral eyes (all P-values >0.20).
In a second step of the statistical analysis, we searched for associations between SFCT and other parameters in the control group.
It revealed that SFCT was significantly
associated with younger age (P=0.001) and hyperopic refractive error (P=0.049), whereas
SC
gender (P=0.07), horizontal disc diameter (P=0.32) and vertical disc diameter (P=0.07) were not significantly associated with SFCT.
In a third step of the analysis, we performed a multivariate analysis with SFCT as independent variables.
M AN U
dependent variable and age, refractive error and diagnosis of non-arteritic AION as It showed that thinner SFCT was significantly associated with the
diagnosis of non-arteritic AION (P=0.001; standardized regression coefficient beta: -0.37; regression coefficient B: -55; 95%CI: -87, -23), after adjusting for age (P
S0002-9394(14)00552-2
DOI:
10.1016/j.ajo.2014.09.008
Reference:
AJOPHT 9061
To appear in:
American Journal of Ophthalmology
Received Date: 20 May 2014 Revised Date:
3 September 2014
Accepted Date: 4 September 2014
Please cite this article as: Schuster AK, Steinmetz P, Forster TM, Schlichtenbrede FC, Harder BC, Jonas JB, Choroidal Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy, American Journal of Ophthalmology (2014), doi: 10.1016/j.ajo.2014.09.008. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Abstract Purpose:
To examine choroidal thickness in non-arteritic anterior ischemic optic neuropathy
(AION). Design:
Retrospective case control study
Methods: Setting: Eye Clinic, University Medical Center Mannheim, Germany. The study group consisted of patients with non-arteritic AION, and the
RI PT
Study Population:
control group consisted of individuals with a normal fundus. Observation:
Choroidal thickness was measured by enhanced depth imaging of
spectral-domain optical coherence tomography. Main Outcome Measure: Results:
Choroidal thickness.
The study group consisted of 20 patients: 11 patients with acute non-arteritic AION
previously non-arteritic AION in the contralateral eye. patients (58 eyes).
SC
and an unaffected contralateral eye, and 9 patients with acute unilateral non-arteritic AION and The control group consisted of 58
In multivariate analysis, thinner subfoveal choroidal thickness (SFCT)
M AN U
was associated with the diagnosis of non-arteritic AION (P=0.001; regression coefficient B: -55.1), after adjusting age (P0.20)
(Table 1).
A similar result was obtained for the subgroup of patients with acute unilateral
RI PT
eye.
non-arteritic AION and previous non-arteritic AION in the contralateral eyes (all P-values >0.20).
In a second step of the statistical analysis, we searched for associations between SFCT and other parameters in the control group.
It revealed that SFCT was significantly
associated with younger age (P=0.001) and hyperopic refractive error (P=0.049), whereas
SC
gender (P=0.07), horizontal disc diameter (P=0.32) and vertical disc diameter (P=0.07) were not significantly associated with SFCT.
In a third step of the analysis, we performed a multivariate analysis with SFCT as independent variables.
M AN U
dependent variable and age, refractive error and diagnosis of non-arteritic AION as It showed that thinner SFCT was significantly associated with the
diagnosis of non-arteritic AION (P=0.001; standardized regression coefficient beta: -0.37; regression coefficient B: -55; 95%CI: -87, -23), after adjusting for age (P
