Fang et al. J Transl Med (2015) 13:314 DOI 10.1186/s12967-015-0672-0

Open Access

RESEARCH

Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy Lu Fang1*, Andris H. Ellims1,2, Xiao‑lei Moore1, David A. White1, Andrew J. Taylor1,2, Jaye Chin‑Dusting1 and Anthony M. Dart1,2,3*

Abstract  Background:  Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardio‑ myopathy (HCM). Methods:  Cardiac magnetic resonance imaging with postcontrast T1 mapping was performed to non-invasively quantify diffuse myocardial fibrosis in HCM patients who were classified into two groups (T1