Am J Cancer Res 2015;5(8):2491-2497 www.ajcr.us /ISSN:2156-6976/ajcr0011378
Original Article Clinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer Yao Qi1*, Fan-Ming Kong2*, Qi Deng1, Jing-Yi Li1, Rui Cui1, Ye-Di Pu1, Qiong-Li Zhai3, Ying-Jie Jia2, Yu-Ming Li1 Department of Hematology, Tianjin First Center Hospital, Fukang Road, Nankai District, Tianjin 300192, China; Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin 300193, China; 3Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei Road, Hexi District, Tianjin 300060, China. *Equal contributors. 1 2
Received June 13, 2015; Accepted July 7, 2015; Epub July 15, 2015; Published August 1, 2015 Abstract: Vav1 has been reported to be involved in human cancers, however, the expression and clinical significance of Vav1 in NSCLC are not fully understood. In the present study, we examined the expression of Vav1 in 170 NSCLC patients who underwent radical resection by the immunohistochemical analyses. The association between the Vav1 expression and clinicopathological variables was analyzed. The multivariate Cox proportional hazards model was conducted to determine the prognostic value of Vav1 on the long-term survival. The results showed that the elevated Vav1 expression was correlated positively with lymph node metastasis (P
Original Article Clinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer Yao Qi1*, Fan-Ming Kong2*, Qi Deng1, Jing-Yi Li1, Rui Cui1, Ye-Di Pu1, Qiong-Li Zhai3, Ying-Jie Jia2, Yu-Ming Li1 Department of Hematology, Tianjin First Center Hospital, Fukang Road, Nankai District, Tianjin 300192, China; Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin 300193, China; 3Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei Road, Hexi District, Tianjin 300060, China. *Equal contributors. 1 2
Received June 13, 2015; Accepted July 7, 2015; Epub July 15, 2015; Published August 1, 2015 Abstract: Vav1 has been reported to be involved in human cancers, however, the expression and clinical significance of Vav1 in NSCLC are not fully understood. In the present study, we examined the expression of Vav1 in 170 NSCLC patients who underwent radical resection by the immunohistochemical analyses. The association between the Vav1 expression and clinicopathological variables was analyzed. The multivariate Cox proportional hazards model was conducted to determine the prognostic value of Vav1 on the long-term survival. The results showed that the elevated Vav1 expression was correlated positively with lymph node metastasis (P
