J Cancer Res Clin Oncol (2014) 140:265–269 DOI 10.1007/s00432-013-1559-1
ORIGINAL PAPER
Clinicopathological characteristics and prognosis of mucinous breast carcinoma Ming Zhang · Xiao‑dan Teng · Xin‑xin Guo · Ji‑shuang Zhao · Zhi‑gao Li
Received: 5 October 2013 / Accepted: 20 November 2013 / Published online: 5 December 2013 © Springer-Verlag Berlin Heidelberg 2013
Abstract Purpose The clinical features and prognosis of mucinous breast carcinoma (MBC) are unclear because of its rarity. The aim was to describe the clinicopathological features and prognosis of patients with MBC in comparison with nonmucinous breast carcinoma (NMBC). Furthermore, we described the biological behavior of pure mucinous breast carcinoma (PMBC) by comparing clinicopathological features and prognosis with mixed mucinous breast carcinoma (MMBC). Methods We reviewed the records of 5,872 consecutive patients diagnosed with breast carcinoma who were resected surgically from March 2003 to October 2010. Among them, 117 patients with MBC were compared to 5,575 patients with NMBC. Furthermore, 88 patients with PMBC were compared to 29 patients with MMBC. Results There were statistical differences in age, pN stage, ER level, and PR level between the patients with MBC and NMBC. There were statistical differences in pT stage and pN stage between the patients with PMBC and MMBC. The overall five-year survival of patients with MBC was 88.1 % as compared with 81.9 % for patients with NMBC. The overall five-year survival of patients with PMBC was 91.3 % as compared with 80.4 % for patients with MMBC. The overall five-year survival of patients with PMBC was 91.3 % as compared with 81.9 % for patients with NMBC. M. Zhang · X. Teng · X. Guo · Z. Li (*) Department of Breast Surgery, Affiliated Third Hospital of Harbin Medical University, 6 Baojian Road, Harbin 150040, China e-mail: [email protected] J. Zhao Department of Surgery, Hospital of Traditional Chinese Medicine of Suihua City, Suihua 152000, China
Conclusions PMBC tended to have a better prognosis in comparison with other types of breast carcinoma. Keywords Breast cancer · Mucinous · Prognosis · Survival
Introduction Mucinous carcinoma of the breast was first described in 1826, but it was and remained one of the uncommon pathological categories in breast cancer (Geschickter 1938; Li et al. 2005). Mucinous carcinoma of the breast is not a common disease, and the incidence of mucinous carcinoma was reported to range from 1 to 6 % of all primary breast cancers (Louwman et al. 2007; Andre et al. 1995; Diab et al. 1999). Mucinous breast carcinoma (MBC) is an invasive neoplasm with clusters of tumor cells floating in pools of extracellular mucin. Mucinous carcinoma is usually seen in elderly and postmenopausal patients and is generally considered to have a favorable prognosis. Mucinous tumors generally had a high proportion of hormone receptor expression (Walsh and Bleiweiss 2001). Mucinous carcinoma of the breast is further divided into pure and mixed subgroups according to the quantification of tumor cellularity. Pure mucinous breast carcinoma (PMBC) contains a higher degree of mucin than mixed mucinous breast carcinoma (MMBC). In this study, we considered tumors with more than 90 % mucinous component to be PMBC and less than 90 % mucinous component to be MMBC (Rosen 2009). PMBC has a better prognosis than MMBC (Di Saverio et al. 2008; Barkley et al. 2008; Fentiman et al. 1997). The clinical features and prognosis of MBC are unclear because of its rarity.
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In the present study, we retrospectively analyzed the records of patients with breast carcinoma and described the biological behavior of MBC by comparing clinicopathological features and prognosis with nonmucinous breast carcinoma (NMBC). Furthermore, we described the biological behavior of PMBC by comparing clinicopathological features and prognosis with MMBC.
Patients and methods
J Cancer Res Clin Oncol (2014) 140:265–269
was assessed using the log-rank test. The accepted level of significance was P 50 45 (38.5) pT stage pT1 37 (31.6) pT2 72 (61.5) pT3/4 8 (6.8) pN stage pN0 87 (74.4) pN1 14 (12.0) pN2 9 (7.7) pN3 7 (6.0) ER level Percentage ER
ORIGINAL PAPER
Clinicopathological characteristics and prognosis of mucinous breast carcinoma Ming Zhang · Xiao‑dan Teng · Xin‑xin Guo · Ji‑shuang Zhao · Zhi‑gao Li
Received: 5 October 2013 / Accepted: 20 November 2013 / Published online: 5 December 2013 © Springer-Verlag Berlin Heidelberg 2013
Abstract Purpose The clinical features and prognosis of mucinous breast carcinoma (MBC) are unclear because of its rarity. The aim was to describe the clinicopathological features and prognosis of patients with MBC in comparison with nonmucinous breast carcinoma (NMBC). Furthermore, we described the biological behavior of pure mucinous breast carcinoma (PMBC) by comparing clinicopathological features and prognosis with mixed mucinous breast carcinoma (MMBC). Methods We reviewed the records of 5,872 consecutive patients diagnosed with breast carcinoma who were resected surgically from March 2003 to October 2010. Among them, 117 patients with MBC were compared to 5,575 patients with NMBC. Furthermore, 88 patients with PMBC were compared to 29 patients with MMBC. Results There were statistical differences in age, pN stage, ER level, and PR level between the patients with MBC and NMBC. There were statistical differences in pT stage and pN stage between the patients with PMBC and MMBC. The overall five-year survival of patients with MBC was 88.1 % as compared with 81.9 % for patients with NMBC. The overall five-year survival of patients with PMBC was 91.3 % as compared with 80.4 % for patients with MMBC. The overall five-year survival of patients with PMBC was 91.3 % as compared with 81.9 % for patients with NMBC. M. Zhang · X. Teng · X. Guo · Z. Li (*) Department of Breast Surgery, Affiliated Third Hospital of Harbin Medical University, 6 Baojian Road, Harbin 150040, China e-mail: [email protected] J. Zhao Department of Surgery, Hospital of Traditional Chinese Medicine of Suihua City, Suihua 152000, China
Conclusions PMBC tended to have a better prognosis in comparison with other types of breast carcinoma. Keywords Breast cancer · Mucinous · Prognosis · Survival
Introduction Mucinous carcinoma of the breast was first described in 1826, but it was and remained one of the uncommon pathological categories in breast cancer (Geschickter 1938; Li et al. 2005). Mucinous carcinoma of the breast is not a common disease, and the incidence of mucinous carcinoma was reported to range from 1 to 6 % of all primary breast cancers (Louwman et al. 2007; Andre et al. 1995; Diab et al. 1999). Mucinous breast carcinoma (MBC) is an invasive neoplasm with clusters of tumor cells floating in pools of extracellular mucin. Mucinous carcinoma is usually seen in elderly and postmenopausal patients and is generally considered to have a favorable prognosis. Mucinous tumors generally had a high proportion of hormone receptor expression (Walsh and Bleiweiss 2001). Mucinous carcinoma of the breast is further divided into pure and mixed subgroups according to the quantification of tumor cellularity. Pure mucinous breast carcinoma (PMBC) contains a higher degree of mucin than mixed mucinous breast carcinoma (MMBC). In this study, we considered tumors with more than 90 % mucinous component to be PMBC and less than 90 % mucinous component to be MMBC (Rosen 2009). PMBC has a better prognosis than MMBC (Di Saverio et al. 2008; Barkley et al. 2008; Fentiman et al. 1997). The clinical features and prognosis of MBC are unclear because of its rarity.
13
266
In the present study, we retrospectively analyzed the records of patients with breast carcinoma and described the biological behavior of MBC by comparing clinicopathological features and prognosis with nonmucinous breast carcinoma (NMBC). Furthermore, we described the biological behavior of PMBC by comparing clinicopathological features and prognosis with MMBC.
Patients and methods
J Cancer Res Clin Oncol (2014) 140:265–269
was assessed using the log-rank test. The accepted level of significance was P 50 45 (38.5) pT stage pT1 37 (31.6) pT2 72 (61.5) pT3/4 8 (6.8) pN stage pN0 87 (74.4) pN1 14 (12.0) pN2 9 (7.7) pN3 7 (6.0) ER level Percentage ER
