RESEARCH ARTICLE
Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials Xingchao Shentu, Xin Zhang, Xiajing Tang, Xiaoning Yu* Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China * [email protected]
Abstract OPEN ACCESS Citation: Shentu X, Zhang X, Tang X, Yu X (2016) Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE 11(1): e0146676. doi:10.1371/journal. pone.0146676 Editor: Haotian Lin, Sun Yat-sen University, CHINA Received: September 3, 2015 Accepted: December 20, 2015 Published: January 8, 2016 Copyright: © 2016 Shentu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by Zhejiang KeyLaboratory Fund of China (Grant No. 2011E10006), the National Natural Science Foundation of China (Grant No. 81371000), the Natural Science Foundation of Zhejiang Province (Grant No.LY14H120002), and the Foundation from Health and Family Planning Commission of Zhejiang Province (Grant No. 201347434). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Background We conducted this meta-analysis to compare the outcomes of coaxial microincision cataract surgery (C-MICS) and standard coaxial small incision cataract surgery (C-SICS).
Methods The outcomes of randomized controlled trials (RCTs) reporting C-MICS and C-SICS were collected from PubMed, Web of Science, and The Cochrane Library in May 2015. The final meta-analysis was conducted on the following intraoperative and postoperative outcomes: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), cumulative dissipated energy (CDE), mean surgery time, endothelial cell loss percentage (ECL%), best corrected visual acuity (BCVA), increased central corneal thickness (CCT), laser flare photometry values and surgically induced astigmatism (SIA).
Results A total of 15 RCTs, involving 1136 eyes, were included in the final meta-analysis. No significant between-group differences were detected in EPT, BSS use, CDE, BCVA, laser flare photometry values or increased CCT. However, the C-MICS group showed less SIA (at postoperative day 7: p
Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials Xingchao Shentu, Xin Zhang, Xiajing Tang, Xiaoning Yu* Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China * [email protected]
Abstract OPEN ACCESS Citation: Shentu X, Zhang X, Tang X, Yu X (2016) Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE 11(1): e0146676. doi:10.1371/journal. pone.0146676 Editor: Haotian Lin, Sun Yat-sen University, CHINA Received: September 3, 2015 Accepted: December 20, 2015 Published: January 8, 2016 Copyright: © 2016 Shentu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by Zhejiang KeyLaboratory Fund of China (Grant No. 2011E10006), the National Natural Science Foundation of China (Grant No. 81371000), the Natural Science Foundation of Zhejiang Province (Grant No.LY14H120002), and the Foundation from Health and Family Planning Commission of Zhejiang Province (Grant No. 201347434). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Background We conducted this meta-analysis to compare the outcomes of coaxial microincision cataract surgery (C-MICS) and standard coaxial small incision cataract surgery (C-SICS).
Methods The outcomes of randomized controlled trials (RCTs) reporting C-MICS and C-SICS were collected from PubMed, Web of Science, and The Cochrane Library in May 2015. The final meta-analysis was conducted on the following intraoperative and postoperative outcomes: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), cumulative dissipated energy (CDE), mean surgery time, endothelial cell loss percentage (ECL%), best corrected visual acuity (BCVA), increased central corneal thickness (CCT), laser flare photometry values and surgically induced astigmatism (SIA).
Results A total of 15 RCTs, involving 1136 eyes, were included in the final meta-analysis. No significant between-group differences were detected in EPT, BSS use, CDE, BCVA, laser flare photometry values or increased CCT. However, the C-MICS group showed less SIA (at postoperative day 7: p
