PharmacologyBiochemistry& Behavior,Vol. 39, pp. 625-633. ©Pergamon Press plc. 1991. Printed in the U.S.A.
0091-3057/91 $3.00 + .00
Cocaine-Induced Respiratory Depression in Urethane-Anesthetized Rats: A Possible Mechanism of Cocaine-Induced Death C H U I - C H U N G T S E N G , * R O B E R T W. D E R L E T , t L A R R Y G. S T A R K * A N D T I M O T H Y E. A L B E R T S O N * t
*Department of Medical Pharmacology and Toxicology and "?Division of Emergency Medicine, School of Medicine, University of California, Davis, Davis, CA 95616 R e c e i v e d 10 S e p t e m b e r 1990 TSENG, C.-C., R. W. DERLET, L. G. STARK AND T. E. ALBERTSON. Cocaine-inducedrespiratory depression in urethaneanesthetized rats: A possible mechanism of cocaine-induced death. PHARMACOL BIOCHEM BEHAV 39(3) 625-633, 1991.-Urethane-anesthetized rats were used to study the mechanism of cocaine-induced death. Continuous recording of the changes in five physiological parameters, including respiratory rate (RR), electroencephalogram (EEG), blood pressure (BP), electrocardiogram (ECG), and body temperature (BT), were conducted after intraperitoneal (IP) administration of a single dose of cocaine HC1 (70 mg/kg). In the control group (normothermic with core body temperature 37.7 + 0. I°C and spontaneously breathing), the death rate was 88% (15/17), and the average time to respiratory arrest was 12.99 +__1.40 rain (mean -+SEM). The first set of experiments investigated the contribution of hypothermia to cocaine-induced death. The hypothermic group (core body temperature 33.9-+ 0.3°C and spontaneously breathing) had a death rate of 81.5% (22/27), and an average time to respiratory arrest of 16.70---1.24 min, which was significantly (p
0091-3057/91 $3.00 + .00
Cocaine-Induced Respiratory Depression in Urethane-Anesthetized Rats: A Possible Mechanism of Cocaine-Induced Death C H U I - C H U N G T S E N G , * R O B E R T W. D E R L E T , t L A R R Y G. S T A R K * A N D T I M O T H Y E. A L B E R T S O N * t
*Department of Medical Pharmacology and Toxicology and "?Division of Emergency Medicine, School of Medicine, University of California, Davis, Davis, CA 95616 R e c e i v e d 10 S e p t e m b e r 1990 TSENG, C.-C., R. W. DERLET, L. G. STARK AND T. E. ALBERTSON. Cocaine-inducedrespiratory depression in urethaneanesthetized rats: A possible mechanism of cocaine-induced death. PHARMACOL BIOCHEM BEHAV 39(3) 625-633, 1991.-Urethane-anesthetized rats were used to study the mechanism of cocaine-induced death. Continuous recording of the changes in five physiological parameters, including respiratory rate (RR), electroencephalogram (EEG), blood pressure (BP), electrocardiogram (ECG), and body temperature (BT), were conducted after intraperitoneal (IP) administration of a single dose of cocaine HC1 (70 mg/kg). In the control group (normothermic with core body temperature 37.7 + 0. I°C and spontaneously breathing), the death rate was 88% (15/17), and the average time to respiratory arrest was 12.99 +__1.40 rain (mean -+SEM). The first set of experiments investigated the contribution of hypothermia to cocaine-induced death. The hypothermic group (core body temperature 33.9-+ 0.3°C and spontaneously breathing) had a death rate of 81.5% (22/27), and an average time to respiratory arrest of 16.70---1.24 min, which was significantly (p
