Accepted Manuscript Cocaine Related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection Joshua H. Dean , Elise M. Woznicki , BS Patrick O’Gara , MD Daniel G. Montgomery , BS Santi Trimarchi , MD PhD Truls Myrmel , MD PhD Reed E. Pyeritz , MD PhD Kevin M. Harris , MD Toru Suzuki , MD PhD Alan C. Braverman , MD G. Chad Hughes , MD Eva Kline-Rogers , MS RN NP Christoph A. Nienaber , MD Eric M. Isselbacher , MD Kim A. Eagle , MD Eduardo Bossone , MD PhD. PII:
S0002-9343(14)00391-X
DOI:
10.1016/j.amjmed.2014.05.005
Reference:
AJM 12521
To appear in:
The American Journal of Medicine
Received Date: 2 April 2014 Revised Date:
1 May 2014
Accepted Date: 2 May 2014
Please cite this article as: Dean JH, Woznicki EM, O’Gara P, Montgomery DG, Trimarchi S, Myrmel T, Pyeritz RE, Harris KM, Suzuki T, Braverman AC, Hughes GC, Kline-Rogers E, Nienaber CA, Isselbacher EM, Eagle KA, Bossone E, Cocaine Related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection, The American Journal of Medicine (2014), doi: 10.1016/j.amjmed.2014.05.005. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Cocaine Related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection Joshua H. Dean1, Elise M. Woznicki1 BS, Patrick O’Gara2 MD, Daniel G. Montgomery1 BS, Santi Trimarchi3 MD PhD, Truls Myrmel4 MD PhD, Reed E. Pyeritz5 MD PhD, Kevin M. Harris6 MD, Toru Suzuki7 MD PhD,
RI PT
Alan C. Braverman8 MD, G. Chad Hughes9 MD, Eva Kline-Rogers1 MS RN NP, Christoph A. Nienaber10 MD, Eric M. Isselbacher11 MD, Kim A. Eagle1 MD, Eduardo Bossone12 MD PhD. Cardiovascular Center, University of Michigan, Ann Arbor, MI, United States
2.
Cardiology Department, Brigham & Women’s Hospital, Boston, MA, United States
3.
Thoracic Aortic Research Center, IRCCS Policlinico San Donato, San Donato, Italy
4.
Department of Thoracic and Cardiovascular Surgery, Tromso University Hospital, Tromso, Norway
5.
Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania,
SC
1.
M AN U
Philadelphia, PA, United States 6.
Cardiovascular Division, Minneapolis Heart Institute, Minneapolis, MN, United States
7.
Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
8.
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, United States
9.
Division of Thoracic Cardiovascular Surgery, Duke University Medical Center, Durham, NC, United States Division of Cardiology and Vascular Medicine, University of Rostock, Rostock, Germany
11.
Thoracic Aortic Center, Massachusetts General Hospital, Boston, MA, United States
12.
Cardiology Division, University of Salerno, Salerno, Italy
TE D
10.
AC C
EP
Address for Correspondance: Eduardo Bossone, M.D., Ph.D, F.E.S.C., F.C.C.P., F.A.C.C. Director, Cardiology Division, "Cava de' Tirreni and Amalfi Coast" Hospital Heart Dept., University of Salerno - Italy. Via Pr. Amedeo, 36 - 83023 Lauro (AV), Italy Fax +39-081-8240067 Cell. +39- 328-5415438 email: [email protected]
Funding: The International Registry of Acute Aortic Dissection receives funding from W.L. Gore & Associates, Inc., Medtronic, Varbedian Aortic Research Fund, the Hewlett Foundation, the Mardigian Foundation, UM Faculty Group Practice, Terumo, and Robert and Anne Aikens. Conflict of Interest: Kim Eagle- W.L. Gore & Associates, Inc., Medtronic, Hewlett Foundation, NIH NHLBI All authors had access to the data and a role in writing the manuscript. Manuscript Type: Clinical Research Study Keywords: Acute Aortic Dissection, Cocaine, Outcomes Word count: 2,933 Running Head: Cocaine and Acute Aortic Dissection
ACCEPTED MANUSCRIPT 2 Abstract Background Acute Aortic Dissection (AAD) associated with cocaine use is rare and has been
RI PT
predominantly reported as single cases or in small patient cohorts. Methods
Our study analyzed 3584 patients enrolled in the International Registry of Acute Aortic
SC
Dissection from 1996 to 2012. We divided the population based on documented cocaine use (C+) versus non-cocaine use (C-) and further stratified the cohorts into Type A (33 C+/2332,
M AN U
1.4%) and Type B (30 C+/1252, 2.4%) dissection. Results
C+ patients presented at a younger age and were more likely to be male and black. Type B dissections were more common among C+ patients than in C- patients. Cocaine-related AAD
TE D
was reported more often at US compared to European sites (86.4% 51/63 v. 13.6% 8/63, p
S0002-9343(14)00391-X
DOI:
10.1016/j.amjmed.2014.05.005
Reference:
AJM 12521
To appear in:
The American Journal of Medicine
Received Date: 2 April 2014 Revised Date:
1 May 2014
Accepted Date: 2 May 2014
Please cite this article as: Dean JH, Woznicki EM, O’Gara P, Montgomery DG, Trimarchi S, Myrmel T, Pyeritz RE, Harris KM, Suzuki T, Braverman AC, Hughes GC, Kline-Rogers E, Nienaber CA, Isselbacher EM, Eagle KA, Bossone E, Cocaine Related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection, The American Journal of Medicine (2014), doi: 10.1016/j.amjmed.2014.05.005. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Cocaine Related Aortic Dissection: Lessons from the International Registry of Acute Aortic Dissection Joshua H. Dean1, Elise M. Woznicki1 BS, Patrick O’Gara2 MD, Daniel G. Montgomery1 BS, Santi Trimarchi3 MD PhD, Truls Myrmel4 MD PhD, Reed E. Pyeritz5 MD PhD, Kevin M. Harris6 MD, Toru Suzuki7 MD PhD,
RI PT
Alan C. Braverman8 MD, G. Chad Hughes9 MD, Eva Kline-Rogers1 MS RN NP, Christoph A. Nienaber10 MD, Eric M. Isselbacher11 MD, Kim A. Eagle1 MD, Eduardo Bossone12 MD PhD. Cardiovascular Center, University of Michigan, Ann Arbor, MI, United States
2.
Cardiology Department, Brigham & Women’s Hospital, Boston, MA, United States
3.
Thoracic Aortic Research Center, IRCCS Policlinico San Donato, San Donato, Italy
4.
Department of Thoracic and Cardiovascular Surgery, Tromso University Hospital, Tromso, Norway
5.
Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania,
SC
1.
M AN U
Philadelphia, PA, United States 6.
Cardiovascular Division, Minneapolis Heart Institute, Minneapolis, MN, United States
7.
Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
8.
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, United States
9.
Division of Thoracic Cardiovascular Surgery, Duke University Medical Center, Durham, NC, United States Division of Cardiology and Vascular Medicine, University of Rostock, Rostock, Germany
11.
Thoracic Aortic Center, Massachusetts General Hospital, Boston, MA, United States
12.
Cardiology Division, University of Salerno, Salerno, Italy
TE D
10.
AC C
EP
Address for Correspondance: Eduardo Bossone, M.D., Ph.D, F.E.S.C., F.C.C.P., F.A.C.C. Director, Cardiology Division, "Cava de' Tirreni and Amalfi Coast" Hospital Heart Dept., University of Salerno - Italy. Via Pr. Amedeo, 36 - 83023 Lauro (AV), Italy Fax +39-081-8240067 Cell. +39- 328-5415438 email: [email protected]
Funding: The International Registry of Acute Aortic Dissection receives funding from W.L. Gore & Associates, Inc., Medtronic, Varbedian Aortic Research Fund, the Hewlett Foundation, the Mardigian Foundation, UM Faculty Group Practice, Terumo, and Robert and Anne Aikens. Conflict of Interest: Kim Eagle- W.L. Gore & Associates, Inc., Medtronic, Hewlett Foundation, NIH NHLBI All authors had access to the data and a role in writing the manuscript. Manuscript Type: Clinical Research Study Keywords: Acute Aortic Dissection, Cocaine, Outcomes Word count: 2,933 Running Head: Cocaine and Acute Aortic Dissection
ACCEPTED MANUSCRIPT 2 Abstract Background Acute Aortic Dissection (AAD) associated with cocaine use is rare and has been
RI PT
predominantly reported as single cases or in small patient cohorts. Methods
Our study analyzed 3584 patients enrolled in the International Registry of Acute Aortic
SC
Dissection from 1996 to 2012. We divided the population based on documented cocaine use (C+) versus non-cocaine use (C-) and further stratified the cohorts into Type A (33 C+/2332,
M AN U
1.4%) and Type B (30 C+/1252, 2.4%) dissection. Results
C+ patients presented at a younger age and were more likely to be male and black. Type B dissections were more common among C+ patients than in C- patients. Cocaine-related AAD
TE D
was reported more often at US compared to European sites (86.4% 51/63 v. 13.6% 8/63, p
