Cardiovascular Drugs and Therapy 4: 1145-1150, 1990 9 Kluwer Academic Publishers, Boston. Printed in U.S.A.
Comparative Effects of Celiprolol, Propranolol, Oxprenolol, and Atenolol on Respiratory Function in Hypertensive Patients with Chronic Obstructive Lung Disease Roberto FogarL Annalisa ZoppL Franco Tettamanti, Luigi PolettL Giancarlo Rizzardi, Giorgio Fiocchi Department of lnter~lal Medicine and Therapeutics, IRCCS Policlinico S. Matteo, University of Pavia, Italy
Summary. The aim of the study was to compare the pulmonary effects of four beta-blockers with different ancillary properties: propranoiol (non-beta~ selective without ISA), oxprenolol (non-beta1 selective with ISA), atenolol (beta, selective), and celipropol (beta, selective with mild beta~-agonist and alpha2-antagonist activity) in hypertensive patients with chronic obstructive lung disease. Ten asthmatic patients, all males, aged 50-66 years were studied. Entry criteria were a) DBP /> 95 mmHg and 95 mmHg and ~< 115 mmHg; FEV~ < 70% of the theoretical value; and an increase in FEV1 of at least 20% after salbutamol inhalation (200 t~g). Patients with heart failure, A-V disturbances, valvulopathies, obstructive arteriopathies, and renal insufficiency
were excluded from the study. Informed consent was obtained from each patient. After a 2-week washout period on placebo, each patient received propranolol (80 rag/day), oxprenolol (80 rag/day), atenolol (100 rag/day), and celiprolol (200 mg/day)for 1 week according to a randomized, crossover, single-blind (observer-blind) design. Patients were checked at the end of the washout and of each treatment period. They were asked to avoid taking bronchodilators for 24 hours beforehand. On each visit, airway function, assessed by FEV1, forced vital capacity (FVC) and FEV1% (FEVJFVC • 100), was evaluated using a Vitalograph spirometer in both basal condition and 30 minutes after salbutamol inha-
Beta-Blockers in Hypertensives with Lung Disease
1147
Table 1. Effects of the four beta blockers in the study on mean values of F E V . FVC, and FEV~% at rest and 30 minutes after 200 v~g qf salb~tamol. Washout
FEV~ (1) FVC (1) FEV]%
;'p < ~'p < ~'p < dp < "p < fp < ~p
Comparative Effects of Celiprolol, Propranolol, Oxprenolol, and Atenolol on Respiratory Function in Hypertensive Patients with Chronic Obstructive Lung Disease Roberto FogarL Annalisa ZoppL Franco Tettamanti, Luigi PolettL Giancarlo Rizzardi, Giorgio Fiocchi Department of lnter~lal Medicine and Therapeutics, IRCCS Policlinico S. Matteo, University of Pavia, Italy
Summary. The aim of the study was to compare the pulmonary effects of four beta-blockers with different ancillary properties: propranoiol (non-beta~ selective without ISA), oxprenolol (non-beta1 selective with ISA), atenolol (beta, selective), and celipropol (beta, selective with mild beta~-agonist and alpha2-antagonist activity) in hypertensive patients with chronic obstructive lung disease. Ten asthmatic patients, all males, aged 50-66 years were studied. Entry criteria were a) DBP /> 95 mmHg and 95 mmHg and ~< 115 mmHg; FEV~ < 70% of the theoretical value; and an increase in FEV1 of at least 20% after salbutamol inhalation (200 t~g). Patients with heart failure, A-V disturbances, valvulopathies, obstructive arteriopathies, and renal insufficiency
were excluded from the study. Informed consent was obtained from each patient. After a 2-week washout period on placebo, each patient received propranolol (80 rag/day), oxprenolol (80 rag/day), atenolol (100 rag/day), and celiprolol (200 mg/day)for 1 week according to a randomized, crossover, single-blind (observer-blind) design. Patients were checked at the end of the washout and of each treatment period. They were asked to avoid taking bronchodilators for 24 hours beforehand. On each visit, airway function, assessed by FEV1, forced vital capacity (FVC) and FEV1% (FEVJFVC • 100), was evaluated using a Vitalograph spirometer in both basal condition and 30 minutes after salbutamol inha-
Beta-Blockers in Hypertensives with Lung Disease
1147
Table 1. Effects of the four beta blockers in the study on mean values of F E V . FVC, and FEV~% at rest and 30 minutes after 200 v~g qf salb~tamol. Washout
FEV~ (1) FVC (1) FEV]%
;'p < ~'p < ~'p < dp < "p < fp < ~p
