www.nature.com/scientificreports
OPEN
received: 06 January 2016 accepted: 25 April 2016 Published: 13 May 2016
Comprehensive rehabilitation with integrative medicine for subacute stroke: A multicenter randomized controlled trial Jianqiao Fang1,2, Lifang Chen1, Ruijie Ma1, Crystal Lynn Keeler2, Laihua Shen3, Yehua Bao4 & Shouyu Xu5 To determine whether integrative medicine rehabilitation (IMR) that combines conventional rehabilitation (CR) with acupuncture and Chinese herbal medicine has better effects for subacute stroke than CR alone, we conducted a multicenter randomized controlled trial that involved three hospitals in China. Three hundred sixty patients with subacute stroke were randomized into IMR and CR groups. The primary outcome was the Modified Barthel Index (MBI). The secondary outcomes were the National Institutes of Health Stroke Scale (NIHSS), the Fugl-Meyer Assessment (FMA), the mini-mental state examination (MMSE), the Montreal Cognitive Assessment (MoCA), Hamilton’s Depression Scale (HAMD), and the Self-Rating Depression Scale (SDS). All variables were evaluated at week 0 (baseline), week 4 (half-way of intervention), week 8 (after treatment) and week 20 (follow-up). In comparison with the CR group, the IMR group had significantly better improvements (P
OPEN
received: 06 January 2016 accepted: 25 April 2016 Published: 13 May 2016
Comprehensive rehabilitation with integrative medicine for subacute stroke: A multicenter randomized controlled trial Jianqiao Fang1,2, Lifang Chen1, Ruijie Ma1, Crystal Lynn Keeler2, Laihua Shen3, Yehua Bao4 & Shouyu Xu5 To determine whether integrative medicine rehabilitation (IMR) that combines conventional rehabilitation (CR) with acupuncture and Chinese herbal medicine has better effects for subacute stroke than CR alone, we conducted a multicenter randomized controlled trial that involved three hospitals in China. Three hundred sixty patients with subacute stroke were randomized into IMR and CR groups. The primary outcome was the Modified Barthel Index (MBI). The secondary outcomes were the National Institutes of Health Stroke Scale (NIHSS), the Fugl-Meyer Assessment (FMA), the mini-mental state examination (MMSE), the Montreal Cognitive Assessment (MoCA), Hamilton’s Depression Scale (HAMD), and the Self-Rating Depression Scale (SDS). All variables were evaluated at week 0 (baseline), week 4 (half-way of intervention), week 8 (after treatment) and week 20 (follow-up). In comparison with the CR group, the IMR group had significantly better improvements (P
