Accepted Manuscript Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriglyceridemia Hana Malinska, Ph.D., Martina Hüttl, Ph.D., Olena Oliyarnyk, Ph.D., Miriam Bratova, M.Sc., Ludmila Kazdova, Ph.D. PII:
S0899-9007(15)00158-6
DOI:
10.1016/j.nut.2015.03.011
Reference:
NUT 9497
To appear in:
Nutrition
Received Date: 9 December 2014 Revised Date:
25 February 2015
Accepted Date: 12 March 2015
Please cite this article as: Malinska H, Hüttl M, Oliyarnyk O, Bratova M, Kazdova L, Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriglyceridemia, Nutrition (2015), doi: 10.1016/j.nut.2015.03.011. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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ACCEPTED MANUSCRIPT
ACCEPTED MANUSCRIPT 1 2
Conjugated linoleic acid reduces visceral and ectopic lipid accumulation
3
and insulin resistance in chronic severe hypertriglyceridemia
4 Hana Malinska Ph.D., Martina Hüttl Ph.D., Olena Oliyarnyk Ph.D., Miriam Bratova M.Sc.,
6
Ludmila Kazdova Ph.D.
7
Centre for Experimental Medicine
8
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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RI PT
5
9
M AN U
10 Corresponding author:
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Dr Hana Malínská Ph.D.
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Department of Metabolism and Diabetes,
14
Centre for Experimental Medicine,
15
Institute for Clinical and Experimental Medicine,
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Videnska 1958/9, 14021 Prague 4, Czech Republic,
17
Phone: (420) 261365369,
18
Fax: (420) 261363027,
19
Mail: [email protected]
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Word count: 4851
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Figures: 4
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Tables: 4
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ACCEPTED MANUSCRIPT Abstract
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Objective: The metabolic health effects of conjugated linoleic acid (CLA), which is one of the
29
principal polyunsaturated fatty acids, are controversial and still not fully accepted. This study
30
examines the effects of CLA on adiposity, ectopic lipid accumulation and insulin-resistant
31
states in a metabolic syndrome model of non-obese hereditary hypertriglyceridemic rats
32
(HHTg).
33
Methods: Groups of adult male HHTg rats were fed a high carbohydrate diet (70% sucrose)
34
with a 2% mixture of CLA isomers, or with the same amount of sunflower oil (control group)
35
for 2 months.
36
Results: CLA supplementation decreased body weight gain (p
S0899-9007(15)00158-6
DOI:
10.1016/j.nut.2015.03.011
Reference:
NUT 9497
To appear in:
Nutrition
Received Date: 9 December 2014 Revised Date:
25 February 2015
Accepted Date: 12 March 2015
Please cite this article as: Malinska H, Hüttl M, Oliyarnyk O, Bratova M, Kazdova L, Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriglyceridemia, Nutrition (2015), doi: 10.1016/j.nut.2015.03.011. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
AC C
EP
TE D
M AN U
SC
RI PT
ACCEPTED MANUSCRIPT
ACCEPTED MANUSCRIPT 1 2
Conjugated linoleic acid reduces visceral and ectopic lipid accumulation
3
and insulin resistance in chronic severe hypertriglyceridemia
4 Hana Malinska Ph.D., Martina Hüttl Ph.D., Olena Oliyarnyk Ph.D., Miriam Bratova M.Sc.,
6
Ludmila Kazdova Ph.D.
7
Centre for Experimental Medicine
8
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
SC
RI PT
5
9
M AN U
10 Corresponding author:
12
Dr Hana Malínská Ph.D.
13
Department of Metabolism and Diabetes,
14
Centre for Experimental Medicine,
15
Institute for Clinical and Experimental Medicine,
16
Videnska 1958/9, 14021 Prague 4, Czech Republic,
17
Phone: (420) 261365369,
18
Fax: (420) 261363027,
19
Mail: [email protected]
21
EP
AC C
20
22
Word count: 4851
23
Figures: 4
24
Tables: 4
25 26
TE D
11
ACCEPTED MANUSCRIPT Abstract
28
Objective: The metabolic health effects of conjugated linoleic acid (CLA), which is one of the
29
principal polyunsaturated fatty acids, are controversial and still not fully accepted. This study
30
examines the effects of CLA on adiposity, ectopic lipid accumulation and insulin-resistant
31
states in a metabolic syndrome model of non-obese hereditary hypertriglyceridemic rats
32
(HHTg).
33
Methods: Groups of adult male HHTg rats were fed a high carbohydrate diet (70% sucrose)
34
with a 2% mixture of CLA isomers, or with the same amount of sunflower oil (control group)
35
for 2 months.
36
Results: CLA supplementation decreased body weight gain (p
