Corneal thickness in children with growth hormone deficiency: The effect of GH treatment A. Ciresi, R. Morreale, S. Radellini, S. Cillino, C. Giordano PII: DOI: Reference:
S1096-6374(14)20244-9 doi: 10.1016/j.ghir.2014.05.001 YGHIR 1022
To appear in:
Growth Hormone & IGF Research
Received date: Revised date: Accepted date:
10 December 2013 18 March 2014 9 May 2014
Please cite this article as: A. Ciresi, R. Morreale, S. Radellini, S. Cillino, C. Giordano, Corneal thickness in children with growth hormone deficiency: The effect of GH treatment, Growth Hormone & IGF Research (2014), doi: 10.1016/j.ghir.2014.05.001
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Corneal thickness in children with growth hormone deficiency: the effect of GH treatment
RI P
T
Ciresi A.1, Morreale R.2, Radellini S1, Cillino S.2 and Giordano C.1
Biomedical Department of Internal and Specialistic Medicine (DIBIMIS), Section of
Endocrinology, Diabetology and Metabolism, University of Palermo, Palermo, Italy
SC
Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section,
MA NU
University of Palermo, Palermo, Italy.
RUNNING TITLE: Corneal thickness and growth hormone.
CORRESPONDING AUTHOR
ED
Carla Giordano
Section of Endocrinology, Diabetology and Metabolism
University of Palermo
PT
Biomedical Department of Internal and Specialistic Medicine (Di.Bi.M.I.S.)
CE
Piazza delle Cliniche 2, 90127 Palermo, Italy Tel. +39.091.6552109
AC
Fax +39.091.6552123
e-mail: [email protected]
ACCEPTED MANUSCRIPT Abstract Objective The eye represents a target site for GH action, although few data are available in
T
patients with GH deficiency (GHD). Our aim was to evaluate central corneal thickness (CCT) and
RI P
intraocular pressure (IOP) values in GHD children to assess the role played by GHD or GH treatment on these parameters.
SC
Design In 74 prepubertal GHD children (51 M, 23 F, aged 10.4 ± 2.4 years) we measured CCT
MA NU
and IOP before and after 12 months of treatment. A baseline evaluation was also made in 50 healthy children matched for age, gender and body mass index. The study outcome considered CCT and IOP during treatment and their correlations with biochemical and auxological data.
Results No difference in CCT and IOP between GHD children at baseline and controls was found
ED
(all p > 0.005). GHD children after 12 months of therapy showed greater CCT (564.7 ± 13.1 µm) than both baseline values (535.7 ± 17 µm; p
S1096-6374(14)20244-9 doi: 10.1016/j.ghir.2014.05.001 YGHIR 1022
To appear in:
Growth Hormone & IGF Research
Received date: Revised date: Accepted date:
10 December 2013 18 March 2014 9 May 2014
Please cite this article as: A. Ciresi, R. Morreale, S. Radellini, S. Cillino, C. Giordano, Corneal thickness in children with growth hormone deficiency: The effect of GH treatment, Growth Hormone & IGF Research (2014), doi: 10.1016/j.ghir.2014.05.001
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Corneal thickness in children with growth hormone deficiency: the effect of GH treatment
RI P
T
Ciresi A.1, Morreale R.2, Radellini S1, Cillino S.2 and Giordano C.1
Biomedical Department of Internal and Specialistic Medicine (DIBIMIS), Section of
Endocrinology, Diabetology and Metabolism, University of Palermo, Palermo, Italy
SC
Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section,
MA NU
University of Palermo, Palermo, Italy.
RUNNING TITLE: Corneal thickness and growth hormone.
CORRESPONDING AUTHOR
ED
Carla Giordano
Section of Endocrinology, Diabetology and Metabolism
University of Palermo
PT
Biomedical Department of Internal and Specialistic Medicine (Di.Bi.M.I.S.)
CE
Piazza delle Cliniche 2, 90127 Palermo, Italy Tel. +39.091.6552109
AC
Fax +39.091.6552123
e-mail: [email protected]
ACCEPTED MANUSCRIPT Abstract Objective The eye represents a target site for GH action, although few data are available in
T
patients with GH deficiency (GHD). Our aim was to evaluate central corneal thickness (CCT) and
RI P
intraocular pressure (IOP) values in GHD children to assess the role played by GHD or GH treatment on these parameters.
SC
Design In 74 prepubertal GHD children (51 M, 23 F, aged 10.4 ± 2.4 years) we measured CCT
MA NU
and IOP before and after 12 months of treatment. A baseline evaluation was also made in 50 healthy children matched for age, gender and body mass index. The study outcome considered CCT and IOP during treatment and their correlations with biochemical and auxological data.
Results No difference in CCT and IOP between GHD children at baseline and controls was found
ED
(all p > 0.005). GHD children after 12 months of therapy showed greater CCT (564.7 ± 13.1 µm) than both baseline values (535.7 ± 17 µm; p
