CORRECTION
Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2 Sei-Myoung Han, Ye-Rin Coh, Jin-Ok Ahn, Goo Jang, Soo Young Yum, Sung-Keun Kang, Hee-Woo Lee, Hwa-Young Youn
In the graph legend in Panel A of Fig 4, the color for RFP-ATMSCs is incorrect. Please see the corrected Fig 4 here.
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OPEN ACCESS Citation: Han S-M, Coh Y-R, Ahn J-O, Jang G, Yum SY, Kang S-K, et al. (2017) Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2. PLoS ONE 12(8): e0183734. https://doi.org/10.1371/ journal.pone.0183734 Published: August 17, 2017 Copyright: © 2017 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PLOS ONE | https://doi.org/10.1371/journal.pone.0183734 August 17, 2017
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Fig 4. PCR analysis and immunofluorescence of liver markers after 28 days hepatogenic differentiation. (A) The mRNA expression level of albumin (ALB) was strongly expressed in hepatogenically differentiated Oct4/Sox2-ATMSCs, whereas the expression level of α-fetoprotein (AFP) was lower than that of RFP-ATMSCs. The expression levels of transferrin were not significantly different in both cells. Undifferentiated ATMSCs and HepG2 were used as negative and positive controls, respectively. (B) Hepatocyte-like cells from RFP- and Oct4/Sox2-ATMSCs are confirmed by immunofluorescence staining for AFP and ALB. Nuclei were counterstained with Hoecst33342. https://doi.org/10.1371/journal.pone.0183734.g001
Reference 1.
Han S-M, Coh Y-R, Ahn J-O, Jang G, Yum SY, Kang S-K, et al. (2015) Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2. PLoS ONE 10(3): e0108874. https://doi.org/10.1371/journal.pone.0108874 PMID: 25815812
PLOS ONE | https://doi.org/10.1371/journal.pone.0183734 August 17, 2017
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Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2 Sei-Myoung Han, Ye-Rin Coh, Jin-Ok Ahn, Goo Jang, Soo Young Yum, Sung-Keun Kang, Hee-Woo Lee, Hwa-Young Youn
In the graph legend in Panel A of Fig 4, the color for RFP-ATMSCs is incorrect. Please see the corrected Fig 4 here.
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
OPEN ACCESS Citation: Han S-M, Coh Y-R, Ahn J-O, Jang G, Yum SY, Kang S-K, et al. (2017) Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2. PLoS ONE 12(8): e0183734. https://doi.org/10.1371/ journal.pone.0183734 Published: August 17, 2017 Copyright: © 2017 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PLOS ONE | https://doi.org/10.1371/journal.pone.0183734 August 17, 2017
1/2
Fig 4. PCR analysis and immunofluorescence of liver markers after 28 days hepatogenic differentiation. (A) The mRNA expression level of albumin (ALB) was strongly expressed in hepatogenically differentiated Oct4/Sox2-ATMSCs, whereas the expression level of α-fetoprotein (AFP) was lower than that of RFP-ATMSCs. The expression levels of transferrin were not significantly different in both cells. Undifferentiated ATMSCs and HepG2 were used as negative and positive controls, respectively. (B) Hepatocyte-like cells from RFP- and Oct4/Sox2-ATMSCs are confirmed by immunofluorescence staining for AFP and ALB. Nuclei were counterstained with Hoecst33342. https://doi.org/10.1371/journal.pone.0183734.g001
Reference 1.
Han S-M, Coh Y-R, Ahn J-O, Jang G, Yum SY, Kang S-K, et al. (2015) Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2. PLoS ONE 10(3): e0108874. https://doi.org/10.1371/journal.pone.0108874 PMID: 25815812
PLOS ONE | https://doi.org/10.1371/journal.pone.0183734 August 17, 2017
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