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Correlation between the dielectric properties and biological activities of human ex vivo hepatic tissue
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2015 Phys. Med. Biol. 60 2603 (http://iopscience.iop.org/0031-9155/60/6/2603) View the table of contents for this issue, or go to the journal homepage for more Download details: IP Address: 147.8.31.43 This content was downloaded on 05/05/2017 at 02:24 Please note that terms and conditions apply.
You may also be interested in: Electrical impedance characterization of normal and cancerous human hepatic tissue Shlomi Laufer, Antoni Ivorra, Victor E Reuter et al. Ischemic small intestine—in vivo versus ex vivo bioimpedance measurements Runar J Strand-Amundsen, Henrik M Reims, Christian Tronstad et al. Ex vivo electrical impedance measurements on excised hepatic tissue from human patients with metastatic colorectal cancer S Prakash, M P Karnes, E K Sequin et al. Changes in dielectric properties at 460 kHz of kidney and fat during heating Mihaela Pop, Andrea Molckovsky, Lee Chin et al. Correction of EP contributions to the dielectric properties of normal and cancerous breast tissues M R Stoneman, M Kosempa, W D Gregory et al. In vivo electrical conductivity of hepatic tumours Dieter Haemmerich, S T Staelin, J Z Tsai et al. Changes in GAIR after NTIRE of tissue in vivo A Golberg, S Laufer, H D Rabinowitch et al.
Institute of Physics and Engineering in Medicine Phys. Med. Biol. 60 (2015) 2603–2617
Physics in Medicine & Biology doi:10.1088/0031-9155/60/6/2603
Correlation between the dielectric properties and biological activities of human ex vivo hepatic tissue Hang Wang1,4, Yong He2,4, Qingguo Yan3, Fusheng You1, Feng Fu1, Xiuzhen Dong1, Xuetao Shi1 and Min Yang2 1
Department of Biomedical Engineering, Fourth Military Medical University, 169 West Changle Road, 710032, Xi’an, People’s Republic of China 2 Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, 710032, Xi’an, People’s Republic of China 3 Department of Pathology, Fourth Military Medical University, 169 West Changle Road, 710032, Xi’an, People’s Republic of China E-mail: [email protected] and [email protected] Received 21 October 2014, revised 11 January 2015 Accepted for publication 28 January 2015 Published 11 March 2015 Abstract
Dielectric properties are vital biophysical features of biological tissues, and biological activity is an index to ascertain the active state of tissues. This study investigated the potential correlation between the dielectric properties and biological activities of human hepatic tissue with prolonged ex vivo time through correlation and regression analyses. The dielectric properties of 26 cases of normal human hepatic tissue at 10 Hz to 100 MHz were measured from 15 min after isolation to 24 h at 37 °C with 90% humidity. Cell morphologies, including nucleus area (NA) and alteration rate of intercellular area (ICAR), were analyzed as indicators of biological activities. Conductivity, complex resistivity, and NA exhibited opposing changes 1 h after isolation. Relative permittivity and ex vivo time were not closely correlated (p > 0.05). The dielectric properties measured at low frequencies (i.e.
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My IOPscience
Correlation between the dielectric properties and biological activities of human ex vivo hepatic tissue
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2015 Phys. Med. Biol. 60 2603 (http://iopscience.iop.org/0031-9155/60/6/2603) View the table of contents for this issue, or go to the journal homepage for more Download details: IP Address: 147.8.31.43 This content was downloaded on 05/05/2017 at 02:24 Please note that terms and conditions apply.
You may also be interested in: Electrical impedance characterization of normal and cancerous human hepatic tissue Shlomi Laufer, Antoni Ivorra, Victor E Reuter et al. Ischemic small intestine—in vivo versus ex vivo bioimpedance measurements Runar J Strand-Amundsen, Henrik M Reims, Christian Tronstad et al. Ex vivo electrical impedance measurements on excised hepatic tissue from human patients with metastatic colorectal cancer S Prakash, M P Karnes, E K Sequin et al. Changes in dielectric properties at 460 kHz of kidney and fat during heating Mihaela Pop, Andrea Molckovsky, Lee Chin et al. Correction of EP contributions to the dielectric properties of normal and cancerous breast tissues M R Stoneman, M Kosempa, W D Gregory et al. In vivo electrical conductivity of hepatic tumours Dieter Haemmerich, S T Staelin, J Z Tsai et al. Changes in GAIR after NTIRE of tissue in vivo A Golberg, S Laufer, H D Rabinowitch et al.
Institute of Physics and Engineering in Medicine Phys. Med. Biol. 60 (2015) 2603–2617
Physics in Medicine & Biology doi:10.1088/0031-9155/60/6/2603
Correlation between the dielectric properties and biological activities of human ex vivo hepatic tissue Hang Wang1,4, Yong He2,4, Qingguo Yan3, Fusheng You1, Feng Fu1, Xiuzhen Dong1, Xuetao Shi1 and Min Yang2 1
Department of Biomedical Engineering, Fourth Military Medical University, 169 West Changle Road, 710032, Xi’an, People’s Republic of China 2 Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, 710032, Xi’an, People’s Republic of China 3 Department of Pathology, Fourth Military Medical University, 169 West Changle Road, 710032, Xi’an, People’s Republic of China E-mail: [email protected] and [email protected] Received 21 October 2014, revised 11 January 2015 Accepted for publication 28 January 2015 Published 11 March 2015 Abstract
Dielectric properties are vital biophysical features of biological tissues, and biological activity is an index to ascertain the active state of tissues. This study investigated the potential correlation between the dielectric properties and biological activities of human hepatic tissue with prolonged ex vivo time through correlation and regression analyses. The dielectric properties of 26 cases of normal human hepatic tissue at 10 Hz to 100 MHz were measured from 15 min after isolation to 24 h at 37 °C with 90% humidity. Cell morphologies, including nucleus area (NA) and alteration rate of intercellular area (ICAR), were analyzed as indicators of biological activities. Conductivity, complex resistivity, and NA exhibited opposing changes 1 h after isolation. Relative permittivity and ex vivo time were not closely correlated (p > 0.05). The dielectric properties measured at low frequencies (i.e.
