RESEARCH ARTICLE
Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction Dan Zhu☯, Hong Xie¤☯, Xinyu Wang, Ying Liang, Haiyi Yu, Wei Gao* Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health (Peking University Third Hospital), Beijing, China
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☯ These authors contributed equally to this work. ¤ Current address: Department of Cancer Biology, Perelman School of Medicine at University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA * [email protected]
Abstract OPEN ACCESS Citation: Zhu D, Xie H, Wang X, Liang Y, Yu H, Gao W (2015) Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction. PLoS ONE 10(4): e0122993. doi:10.1371/ journal.pone.0122993 Academic Editor: Yan Gong, University of Florida, UNITED STATES Received: October 21, 2014 Accepted: February 26, 2015 Published: April 7, 2015 Copyright: © 2015 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by grants from the National Natural Science Foundation of China (No. 81200167) and the Ph.D. Programs Foundation of the Ministry of Education of China (No. 20120001120131), and the International cooperation projects of the Ministry of Science and Technology (No. 2013DFG32940). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI. 100 participants recruited were all patients with AMI, all of who received successful primary percutaneous coronary intervention (PCI) within 12h from the AMI symptom onset in our center; the concentrations of plasma catestatin were evaluated from blood samples of those 100 participants. Subsequent 65 months' follow-up was performed after discharging to evaluate cardiac adverse events and the association between catestatin levels and prognosis of AMI was examined. We confirmed the dramatic change of catestatin concentrations in the first week of AMI, and the levels of catestatin on D3 were much higher in adverse events group than those in non-adverse events group (p
Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction Dan Zhu☯, Hong Xie¤☯, Xinyu Wang, Ying Liang, Haiyi Yu, Wei Gao* Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health (Peking University Third Hospital), Beijing, China
a11111
☯ These authors contributed equally to this work. ¤ Current address: Department of Cancer Biology, Perelman School of Medicine at University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA * [email protected]
Abstract OPEN ACCESS Citation: Zhu D, Xie H, Wang X, Liang Y, Yu H, Gao W (2015) Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction. PLoS ONE 10(4): e0122993. doi:10.1371/ journal.pone.0122993 Academic Editor: Yan Gong, University of Florida, UNITED STATES Received: October 21, 2014 Accepted: February 26, 2015 Published: April 7, 2015 Copyright: © 2015 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by grants from the National Natural Science Foundation of China (No. 81200167) and the Ph.D. Programs Foundation of the Ministry of Education of China (No. 20120001120131), and the International cooperation projects of the Ministry of Science and Technology (No. 2013DFG32940). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI. 100 participants recruited were all patients with AMI, all of who received successful primary percutaneous coronary intervention (PCI) within 12h from the AMI symptom onset in our center; the concentrations of plasma catestatin were evaluated from blood samples of those 100 participants. Subsequent 65 months' follow-up was performed after discharging to evaluate cardiac adverse events and the association between catestatin levels and prognosis of AMI was examined. We confirmed the dramatic change of catestatin concentrations in the first week of AMI, and the levels of catestatin on D3 were much higher in adverse events group than those in non-adverse events group (p
