Clinical and Experimental Ophthalmology 2014; 42: 511–512 doi: 10.1111/ceo.12394
Editorial Counting on caveolin for clues in glaucoma Primary open angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. Over the last two decades, there has been a great deal of research aimed at understanding the causes of the POAG and significant progress has been made in dissecting its genetic architecture. Several familybased studies found single-gene POAG-causing mutations, which are transmitted as a Mendelian trait, often with an autosomal dominant inheritance pattern. However, when considered together, Mendelian genes causing glaucoma only account for