Open Forum Infectious Diseases MAJOR ARTICLE
Cryptococcal Antigenemia in Nigerian Patients With Advanced Human Immunodeficiency Virus: Influence of Antiretroviral Therapy Adherence Rita O. Oladele,1,2 Alani S. Akanmu,3 Augustina O. Nwosu,4 Folasade T. Ogunsola,2 Malcolm D. Richardson,1,5 and David W. Denning1,5 1 The University of Manchester, United Kingdom; 2College of Medicine of University of Lagos, 3US President’s Emergency Plan for AIDS Relief Clinic, Lagos University Teaching Hospital, and 4AIDS Prevention Initiative in Nigeria, Central Laboratory, College of Medicine of University of Lagos, Nigeria; 5National Aspergillosis Centre and Mycology Reference Centre Manchester, University Hospital of South Manchester and Manchester Academic Health Science Centre, United Kingdom
Background. Cryptococcal meningitis has a high mortality in human immunodeficiency virus (HIV)-infected persons in Africa. This is preventable with early screening and preemptive therapy. We evaluated the prevalence of cryptococcal disease by antigen testing, possible associated factors, and outcomes in HIV-infected patients being managed in a tertiary hospital in Lagos, Nigeria. Methods. Sera were collected from 214 consenting HIV-infected participants with CD4+ counts
Cryptococcal Antigenemia in Nigerian Patients With Advanced Human Immunodeficiency Virus: Influence of Antiretroviral Therapy Adherence Rita O. Oladele,1,2 Alani S. Akanmu,3 Augustina O. Nwosu,4 Folasade T. Ogunsola,2 Malcolm D. Richardson,1,5 and David W. Denning1,5 1 The University of Manchester, United Kingdom; 2College of Medicine of University of Lagos, 3US President’s Emergency Plan for AIDS Relief Clinic, Lagos University Teaching Hospital, and 4AIDS Prevention Initiative in Nigeria, Central Laboratory, College of Medicine of University of Lagos, Nigeria; 5National Aspergillosis Centre and Mycology Reference Centre Manchester, University Hospital of South Manchester and Manchester Academic Health Science Centre, United Kingdom
Background. Cryptococcal meningitis has a high mortality in human immunodeficiency virus (HIV)-infected persons in Africa. This is preventable with early screening and preemptive therapy. We evaluated the prevalence of cryptococcal disease by antigen testing, possible associated factors, and outcomes in HIV-infected patients being managed in a tertiary hospital in Lagos, Nigeria. Methods. Sera were collected from 214 consenting HIV-infected participants with CD4+ counts
