Eur J Nucl Med Mol Imaging (2015) 42:56–65 DOI 10.1007/s00259-014-2902-8
ORIGINAL ARTICLE
[18F]FDG PET/MRI vs. PET/CT for whole-body staging in patients with recurrent malignancies of the female pelvis: initial results Karsten Beiderwellen & Johannes Grueneisen & Verena Ruhlmann & Paul Buderath & Bahriye Aktas & Philipp Heusch & Oliver Kraff & Michael Forsting & Thomas C. Lauenstein & Lale Umutlu
Received: 5 May 2014 / Accepted: 25 August 2014 / Published online: 16 September 2014 # Springer-Verlag Berlin Heidelberg 2014
K. Beiderwellen (*) : J. Grueneisen : M. Forsting : T. C. Lauenstein : L. Umutlu Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany e-mail: [email protected]
count, lesion localization, lesion conspicuity (four-point scale), lesion characterization (benign/malignant/indeterminate) and diagnostic confidence (three-point scale). All available data (histology, prior examinations, PET/CT, PET/MRI, follow-up examinations) served as standard of reference. Median values were compared using the Wilcoxon rank sum test. Results Metastatic lesions were present in 16 of the 19 patients. A total of 78 lesions (malignant, 58; benign, 20) were described. Both PET/CT and PET/MRI allowed correct identification of all malignant lesions and provided equivalent conspicuity (3.86±0.35 for PET/CT, 3.91±0.28 for PET/ MRI; p> 0.05). Diagnostic confidence was significantly higher for PET/MRI in malignant (p0.05 >0.05 >0.05 0.05 >0.05 >0.05
show an early peak age of diagnosis between the ages of 35 and 75 years [18]. Hence, repeated follow-up examinations in these patients may lead to a considerable cumulative radiation dose. According to calculations of Brix et al., radiation exposure from a whole-body PET/CT scan including a diagnostic CT scan can amount to 25 mSv with 5.7 – 7 mSv from the tracer and 14.1 – 18.6 mSv from the diagnostic CT scan [19]. While the CT scan of a low-dose PET/CT scan accounts for 5 mm in size, PET-positive), but two granulomas (0.05 0.05 >0.05
ORIGINAL ARTICLE
[18F]FDG PET/MRI vs. PET/CT for whole-body staging in patients with recurrent malignancies of the female pelvis: initial results Karsten Beiderwellen & Johannes Grueneisen & Verena Ruhlmann & Paul Buderath & Bahriye Aktas & Philipp Heusch & Oliver Kraff & Michael Forsting & Thomas C. Lauenstein & Lale Umutlu
Received: 5 May 2014 / Accepted: 25 August 2014 / Published online: 16 September 2014 # Springer-Verlag Berlin Heidelberg 2014
K. Beiderwellen (*) : J. Grueneisen : M. Forsting : T. C. Lauenstein : L. Umutlu Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany e-mail: [email protected]
count, lesion localization, lesion conspicuity (four-point scale), lesion characterization (benign/malignant/indeterminate) and diagnostic confidence (three-point scale). All available data (histology, prior examinations, PET/CT, PET/MRI, follow-up examinations) served as standard of reference. Median values were compared using the Wilcoxon rank sum test. Results Metastatic lesions were present in 16 of the 19 patients. A total of 78 lesions (malignant, 58; benign, 20) were described. Both PET/CT and PET/MRI allowed correct identification of all malignant lesions and provided equivalent conspicuity (3.86±0.35 for PET/CT, 3.91±0.28 for PET/ MRI; p> 0.05). Diagnostic confidence was significantly higher for PET/MRI in malignant (p0.05 >0.05 >0.05 0.05 >0.05 >0.05
show an early peak age of diagnosis between the ages of 35 and 75 years [18]. Hence, repeated follow-up examinations in these patients may lead to a considerable cumulative radiation dose. According to calculations of Brix et al., radiation exposure from a whole-body PET/CT scan including a diagnostic CT scan can amount to 25 mSv with 5.7 – 7 mSv from the tracer and 14.1 – 18.6 mSv from the diagnostic CT scan [19]. While the CT scan of a low-dose PET/CT scan accounts for 5 mm in size, PET-positive), but two granulomas (0.05 0.05 >0.05
