Eur Radiol DOI 10.1007/s00330-014-3240-8

UROGENITAL

Preoperative lymph node staging in patients with primary prostate cancer: comparison and correlation of quantitative imaging parameters in diffusion-weighted imaging and 11C-choline PET/CT Tibor Vag & Matthias M. Heck & Ambros J. Beer & Michael Souvatzoglou & Gregor Weirich & Konstantin Holzapfel & Bernd Joachim Krause & Markus Schwaiger & Matthias Eiber & Ernst J. Rummeny

Received: 18 January 2014 / Revised: 3 May 2014 / Accepted: 13 May 2014 # European Society of Radiology 2014

Abstract Purpose To compare the diagnostic performance of DWI and 11C-choline PET/CT in the assessment of preoperative lymph node status in patients with primary prostate cancer. Material and methods Thirty-three patients underwent DWI and 11C-choline PET/CT prior to prostatectomy and extended pelvic lymph node dissection. Mean standardised uptake value (SUVmean) and mean apparent diffusion coefficient (ADC) of 76 identified lymph nodes (LN) were measured and correlated with histopathology. ADC values and SUVs were compared using linear regression analysis. Results A significant difference between benign and malignant LN was observed for ADC values (1.17 vs. 0.96×10-3 mm2/s; T. Vag (*) : A. J. Beer : M. Souvatzoglou : M. Schwaiger Clinic of Nuclear Medicine, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany e-mail: [email protected] M. M. Heck Clinic of Urology, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany G. Weirich Institute of Pathology, Klinikum Rechts der Isar, Technical University Munich, Trogerstrasse 18, 81675 Munich, Germany K. Holzapfel : M. Eiber : E. J. Rummeny Institute of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany B. J. Krause Clinic of Nuclear Medicine, University Hospital Rostock, Getrudenplatz 1, 18057 Rostock, Germany

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To compare the diagnostic performance of DWI and 11C-choline PET/CT in the assessment of preoperative lymph node status in patients with primary prost...
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