Images in Cardiothoracic Medicine and Surgery
Cystic hamartoma of the posterior mediastinum
Asian Cardiovascular & Thoracic Annals 2015, Vol. 23(5) 605–606 ß The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0218492314523768 aan.sagepub.com
Andrew C Chatzis1, Lucas Kaklamanis2 and Prodromos Azariadis1
Figure 1. Computed tomography clearly depicting a high posterior mediastinal cystic tumor.
Routine investigations for muscular dystrophy (Becker’s disease) in a 17-year-old female unveiled a cystic lesion of the posterior mediastinum (Figure 1). At operation via a standard right posterolateral thoracotomy, a cystic tumor of 4.5 cm in diameter was encountered between the esophagus and the trachea and removed (Figure 2a, 2b). Histology revealed a cystic hamartoma (Figure 2c). The patient remained well with no signs of recurrence 3 years later. Hamartomas of the lung are rare, and as yet there are
1 Department of Pediatric and Congenital Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece 2 Department of Pathology, Onassis Cardiac Surgery Center, Athens, Greece
Corresponding author: Andrew C Chatzis, MD, Department of Pediatric and Congenital Cardiac Surgery, Onassis Cardiac Surgery Center, 356 Syngrou Ave., Kallithea 17674, Athens, Greece. Email: [email protected]
Downloaded from aan.sagepub.com at DEAKIN UNIV LIBRARY on November 14, 2015
606
Asian Cardiovascular & Thoracic Annals 23(5)
Figure 2. (a) Operative view of the tumor and its relation to the azygous vein. (b) The resected tumor. (c) Histology showing a hamartomatous cystic lesion consisting of small cysts covered by respiratory epithelium with scattered cartilaginous tissue in the stroma.
no published reports of a mediastinal location. Muscular dystrophy has been associated with various tumors, and certain molecular mechanisms thought to be of importance in determining the classic myotonic dystrophy phenotype have been shown to have links to previously described oncogenic pathways.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Conflict of interest statement None declared.
Downloaded from aan.sagepub.com at DEAKIN UNIV LIBRARY on November 14, 2015
Cystic hamartoma of the posterior mediastinum
Asian Cardiovascular & Thoracic Annals 2015, Vol. 23(5) 605–606 ß The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0218492314523768 aan.sagepub.com
Andrew C Chatzis1, Lucas Kaklamanis2 and Prodromos Azariadis1
Figure 1. Computed tomography clearly depicting a high posterior mediastinal cystic tumor.
Routine investigations for muscular dystrophy (Becker’s disease) in a 17-year-old female unveiled a cystic lesion of the posterior mediastinum (Figure 1). At operation via a standard right posterolateral thoracotomy, a cystic tumor of 4.5 cm in diameter was encountered between the esophagus and the trachea and removed (Figure 2a, 2b). Histology revealed a cystic hamartoma (Figure 2c). The patient remained well with no signs of recurrence 3 years later. Hamartomas of the lung are rare, and as yet there are
1 Department of Pediatric and Congenital Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece 2 Department of Pathology, Onassis Cardiac Surgery Center, Athens, Greece
Corresponding author: Andrew C Chatzis, MD, Department of Pediatric and Congenital Cardiac Surgery, Onassis Cardiac Surgery Center, 356 Syngrou Ave., Kallithea 17674, Athens, Greece. Email: [email protected]
Downloaded from aan.sagepub.com at DEAKIN UNIV LIBRARY on November 14, 2015
606
Asian Cardiovascular & Thoracic Annals 23(5)
Figure 2. (a) Operative view of the tumor and its relation to the azygous vein. (b) The resected tumor. (c) Histology showing a hamartomatous cystic lesion consisting of small cysts covered by respiratory epithelium with scattered cartilaginous tissue in the stroma.
no published reports of a mediastinal location. Muscular dystrophy has been associated with various tumors, and certain molecular mechanisms thought to be of importance in determining the classic myotonic dystrophy phenotype have been shown to have links to previously described oncogenic pathways.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Conflict of interest statement None declared.
Downloaded from aan.sagepub.com at DEAKIN UNIV LIBRARY on November 14, 2015
