ORIGINAL ARTICLE

https://doi.org/10.4046/trd.2017.80.3.277 ISSN: 1738-3536(Print)/2005-6184(Online) • Tuberc Respir Dis 2017;80:277-283

Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease Yun Su Sim, M.D., Ph.D.1, Jin Hwa Lee, M.D., Ph.D.2, Ki Uk Kim, M.D., Ph.D.3, Seung Won Ra, M.D., Ph.D.4, Hye Yun Park, M.D., Ph.D.5, Chang-Hoon Lee, M.D., Ph.D.6, Deog Kyeom Kim, M.D., Ph.D.7, Kyeong-Cheol Shin, M.D., Ph.D.8, Sang Haak Lee, M.D., Ph.D.9, Hun Gyu Hwang, M.D., Ph.D.10, Joong Hyun Ahn, M.D., Ph.D.11, Yong Bum Park, M.D.12, Yu-Il Kim, M.D., Ph.D.13, Kwang Ha Yoo, M.D., Ph.D.14, Ina Jeong, M.D.15, Yeon-Mok Oh, M.D., Ph.D.16 and Sang-Do Lee, M.D., Ph.D.16, on behalf of the KOLD Investigators *Author affiliations appear at the end of this article.

Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036–1.596; p=0.023), age