Response Letter
Determinants That May Affect Serum Uric Acid Levels
Angiology 2014, Vol. 65(3) 238 ª The Author(s) 2013 Reprints and permission: sagepub.com/journalsPermissions.nav DOI: 10.1177/0003319713510060 ang.sagepub.com
Onur Kadir Uysal, MD1, Mustafa Duran, MD1, Durmus Yildiray Sahin, MD2, Bugra Ozkan, MD2, Kamuran Tekin, MD2, Mustafa Gur, MD2, and Murat Cayli, MD2
We reported that high levels of serum uric acid (SUA) were associated with poor coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD).1 We thank Canpolat et al for their comments on our manuscript.2 They 2 comment on the lack of data about cardiovascular medication, renal function, and components of metabolic syndrome (MetS) in our study. As we mentioned in the limitation section, this was a substantial limitation as a result of the study design. Many drugs can influence SUA levels. 3 These include statins and drugs specifically aimed at that function (eg, allopurinol); thiazides raise SUA levels. Moreover, several studies have reported that SUA levels were associated with glomerular filtration rate and MetS. 4,5 Further studies are needed to clarify the exact mechanisms linking SUA and poor CCC in patients with stable CAD, and all of these limitations in our study must be included.
References 1. Uysal OK, Sahin DY, Duran M, et al. Association between uric acid and coronary collateral circulation in patients with stable coronary artery. Angiology. 2014;65(3):227-231. 2. Canpolat U, Cagli K, Aras D, Kisacik HL, Aydogdu S. The association of serum uric acid level with coronary collateral circulation should be interpreted together with renal function and cardiovascular medications in stable coronary artery disease. Angiology. 2014;65(3): 236-237. 3. Daskalopoulou SS, Tzovaras V, Mikhailidis DP, Elisaf M. Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricemia. Curr Pharm Des. 2005;11(32):4161-4175. 4. Kanbay M, Ozkara A, Selcoki Y, et al. Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearance, and proteinuria in patients with normal renal functions. Int Urol Nephrol. 2007;39(4):1227-1233. 5. Hergenc G, Onat A, Turkmen S, et al. Uric acid levels in Turkish adults: a determinant of metabolic syndrome and a marker of coronary disease, especially in women. Turk Kardiyol Dern Ars. 2004;32(2):71-81.
1
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey 2 Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey Corresponding Author: Onur Kadir Uysal, Department of Cardiology, Kayseri Education and Research Hospital, Hastaneler Caddesi, No: 78, Kocasinan, Kayseri, Turkey. Email: [email protected]
Downloaded from ang.sagepub.com at PENNSYLVANIA STATE UNIV on March 14, 2015
Determinants That May Affect Serum Uric Acid Levels
Angiology 2014, Vol. 65(3) 238 ª The Author(s) 2013 Reprints and permission: sagepub.com/journalsPermissions.nav DOI: 10.1177/0003319713510060 ang.sagepub.com
Onur Kadir Uysal, MD1, Mustafa Duran, MD1, Durmus Yildiray Sahin, MD2, Bugra Ozkan, MD2, Kamuran Tekin, MD2, Mustafa Gur, MD2, and Murat Cayli, MD2
We reported that high levels of serum uric acid (SUA) were associated with poor coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD).1 We thank Canpolat et al for their comments on our manuscript.2 They 2 comment on the lack of data about cardiovascular medication, renal function, and components of metabolic syndrome (MetS) in our study. As we mentioned in the limitation section, this was a substantial limitation as a result of the study design. Many drugs can influence SUA levels. 3 These include statins and drugs specifically aimed at that function (eg, allopurinol); thiazides raise SUA levels. Moreover, several studies have reported that SUA levels were associated with glomerular filtration rate and MetS. 4,5 Further studies are needed to clarify the exact mechanisms linking SUA and poor CCC in patients with stable CAD, and all of these limitations in our study must be included.
References 1. Uysal OK, Sahin DY, Duran M, et al. Association between uric acid and coronary collateral circulation in patients with stable coronary artery. Angiology. 2014;65(3):227-231. 2. Canpolat U, Cagli K, Aras D, Kisacik HL, Aydogdu S. The association of serum uric acid level with coronary collateral circulation should be interpreted together with renal function and cardiovascular medications in stable coronary artery disease. Angiology. 2014;65(3): 236-237. 3. Daskalopoulou SS, Tzovaras V, Mikhailidis DP, Elisaf M. Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricemia. Curr Pharm Des. 2005;11(32):4161-4175. 4. Kanbay M, Ozkara A, Selcoki Y, et al. Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearance, and proteinuria in patients with normal renal functions. Int Urol Nephrol. 2007;39(4):1227-1233. 5. Hergenc G, Onat A, Turkmen S, et al. Uric acid levels in Turkish adults: a determinant of metabolic syndrome and a marker of coronary disease, especially in women. Turk Kardiyol Dern Ars. 2004;32(2):71-81.
1
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey 2 Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey Corresponding Author: Onur Kadir Uysal, Department of Cardiology, Kayseri Education and Research Hospital, Hastaneler Caddesi, No: 78, Kocasinan, Kayseri, Turkey. Email: [email protected]
Downloaded from ang.sagepub.com at PENNSYLVANIA STATE UNIV on March 14, 2015
