Determination of Zolpidem and Zopiclone in Serum by Capillary Column Gas Chromatography D. DEBRUYNE*',J. LACOTTE*, B. HURAULTDE LIGNY*,
AND M.
MOULIN*
Received October 10, 1989, from the 'Laboratory of Pharmacology, and the 'Division of Nephrology, Caen University Hospital Center, Accepted for publication February 21, 1990. 14032 Caen Cedex, France. Abstract 0 A gas chromatographic method using a short, highresolution capillary column connected to a specific thermoionic detector and requiring a simple and short extraction step without evaporation was developed for the rapid and precise determination of two new hypnotics, zolpidem and zopiclone, in serum at concentrations >5 ng/mL. The assay was linear between 5 and 200 nglmL, with coefficients of intra- and interassay variation
AND M.
MOULIN*
Received October 10, 1989, from the 'Laboratory of Pharmacology, and the 'Division of Nephrology, Caen University Hospital Center, Accepted for publication February 21, 1990. 14032 Caen Cedex, France. Abstract 0 A gas chromatographic method using a short, highresolution capillary column connected to a specific thermoionic detector and requiring a simple and short extraction step without evaporation was developed for the rapid and precise determination of two new hypnotics, zolpidem and zopiclone, in serum at concentrations >5 ng/mL. The assay was linear between 5 and 200 nglmL, with coefficients of intra- and interassay variation
