Clin Physiol Funct Imaging (2016) 36, pp17–24
doi: 10.1111/cpf.12188
Diastolic function improves after resolution of takotsubo cardiomyopathy Sanjay Kumar1,2, Micael Waldenborg3, Priya Bhumireddy4, Keshwar Ramkissoon1, Karin Loiske3, Antony L. Innasimuthu1, Richard S. Grodman1, John F. Heitner4, Kent Emilsson3 and Jason M. Lazar1 1 4
€ rebro University Hospital, O € rebro, Sweden and SUNY Downstate Medical Center, Brooklyn, NY, USA, 2Marshfield clinic-weston center, Weston, WI, USA, 3O New York Methodist Hospital, Brooklyn, NY, USA
Summary Correspondence Micael Waldenborg (MSci), Department of Clini€ rebro University Hospital, SEcal Physiology, O € rebro, Sweden 701 85 O E-mail: [email protected]
Accepted for publication Received 11 March 2014; accepted 13 August 2014
Key words broken heart syndrome; doppler; echocardiography; relaxation; stress-induced cardiomyopathy
Background Takotsubo cardiomyopathy (TTC) is a condition of reversible left ventricular (LV) systolic dysfunction. However, the diastolic function (DF) manifestations of TTC have not been widely investigated. We performed a bicentric study with retrospective analysis of DF in patients with TTC, during onset and at follow-up. Methods Twenty-eight patients with TTC (64 10 years, F 24) were included. All underwent echocardiograms acutely and at the recovery phase (average three months later). Diastolic and systolic function parameters were recorded, including E-wave velocity (E), A-wave velocity, E/A ratio, relaxation (e0 ) and contractility (S0 ) based on tissue Doppler velocities of the mitral annuli, ejection fraction (EF), left atrial (LA) size and DF stages. Results Recovery, including the mean difference with 95% confidence interval, was associated with tending improvement (i.e. uncorrected significance) in E [13 cm s1 (24, 23), P = 002] and in E/A ratio [02 (041, 002), P = 004], as well as significant improvement (after multiple comparison correction) in mean e0 [20 cm s1 (33, 12), P
doi: 10.1111/cpf.12188
Diastolic function improves after resolution of takotsubo cardiomyopathy Sanjay Kumar1,2, Micael Waldenborg3, Priya Bhumireddy4, Keshwar Ramkissoon1, Karin Loiske3, Antony L. Innasimuthu1, Richard S. Grodman1, John F. Heitner4, Kent Emilsson3 and Jason M. Lazar1 1 4
€ rebro University Hospital, O € rebro, Sweden and SUNY Downstate Medical Center, Brooklyn, NY, USA, 2Marshfield clinic-weston center, Weston, WI, USA, 3O New York Methodist Hospital, Brooklyn, NY, USA
Summary Correspondence Micael Waldenborg (MSci), Department of Clini€ rebro University Hospital, SEcal Physiology, O € rebro, Sweden 701 85 O E-mail: [email protected]
Accepted for publication Received 11 March 2014; accepted 13 August 2014
Key words broken heart syndrome; doppler; echocardiography; relaxation; stress-induced cardiomyopathy
Background Takotsubo cardiomyopathy (TTC) is a condition of reversible left ventricular (LV) systolic dysfunction. However, the diastolic function (DF) manifestations of TTC have not been widely investigated. We performed a bicentric study with retrospective analysis of DF in patients with TTC, during onset and at follow-up. Methods Twenty-eight patients with TTC (64 10 years, F 24) were included. All underwent echocardiograms acutely and at the recovery phase (average three months later). Diastolic and systolic function parameters were recorded, including E-wave velocity (E), A-wave velocity, E/A ratio, relaxation (e0 ) and contractility (S0 ) based on tissue Doppler velocities of the mitral annuli, ejection fraction (EF), left atrial (LA) size and DF stages. Results Recovery, including the mean difference with 95% confidence interval, was associated with tending improvement (i.e. uncorrected significance) in E [13 cm s1 (24, 23), P = 002] and in E/A ratio [02 (041, 002), P = 004], as well as significant improvement (after multiple comparison correction) in mean e0 [20 cm s1 (33, 12), P
