Original Article
Differences in cardiovascular disease risk when antihypertensive medication adherence is assessed by pharmacy fill versus self-report: the Cohort Study of Medication Adherence among Older Adults (CoSMO) Marie Krousel-Wood a,b,c, Elizabeth Holt b, Cara Joyce d, Rachael Ruiz e, Adriana Dornelles b, Larry S. Webber d, Donald E. Morisky f, Edward D. Frohlich g, Richard N. Re g, Jiang He c, Paul K. Whelton c, and Paul Muntner h
Background: Pharmacy refill adherence assesses the medication-filling behaviors, whereas self-report adherence assesses the medication-taking behaviors. We contrasted the association of pharmacy refill and self-reported antihypertensive medication adherence with blood pressure (BP) control and cardiovascular disease (CVD) incidence. Methods and results: Adults (n ¼ 2075) from the prospective Cohort Study of Medication Adherence among Older Adults recruited between August 2006 and September 2007 were included. Antihypertensive medication adherence was determined using a pharmacy refill measure, medication possession ratio (MPR; low, medium, and high MPR:
Differences in cardiovascular disease risk when antihypertensive medication adherence is assessed by pharmacy fill versus self-report: the Cohort Study of Medication Adherence among Older Adults (CoSMO) Marie Krousel-Wood a,b,c, Elizabeth Holt b, Cara Joyce d, Rachael Ruiz e, Adriana Dornelles b, Larry S. Webber d, Donald E. Morisky f, Edward D. Frohlich g, Richard N. Re g, Jiang He c, Paul K. Whelton c, and Paul Muntner h
Background: Pharmacy refill adherence assesses the medication-filling behaviors, whereas self-report adherence assesses the medication-taking behaviors. We contrasted the association of pharmacy refill and self-reported antihypertensive medication adherence with blood pressure (BP) control and cardiovascular disease (CVD) incidence. Methods and results: Adults (n ¼ 2075) from the prospective Cohort Study of Medication Adherence among Older Adults recruited between August 2006 and September 2007 were included. Antihypertensive medication adherence was determined using a pharmacy refill measure, medication possession ratio (MPR; low, medium, and high MPR:
