G Model
ARTICLE IN PRESS
JVAC-15323; No. of Pages 5
Vaccine xxx (2014) xxx–xxx
Contents lists available at ScienceDirect
Vaccine journal homepage: www.elsevier.com/locate/vaccine
Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer Konrad Bochennek a , Regina Allwinn b,1 , Rebecca Langer a , Martina Becker a , Oliver T. Keppler b , Thomas Klingebiel a , Thomas Lehrnbecher a,∗ a b
Pediatric Hematology and Oncology, Children’s Hospital of the University of Frankfurt, Germany Institute of Medical Virology, University of Frankfurt, Germany
a r t i c l e
i n f o
Article history: Received 30 October 2013 Received in revised form 12 April 2014 Accepted 17 April 2014 Available online xxx Keywords: Vaccination Child Cancer Measles Mumps Rubella Varicella
a b s t r a c t Background: Intensive chemotherapy in children with cancer results in long-term impairment of humoral immunity. Whereas most studies to date focused on children with acute lymphoblastic leukemia (ALL), little data have been published on patients suffering from Hodgkin disease or from solid tumors. We therefore analyzed the loss of protective immunity (defined as immunity at the time of diagnosis and lack of immunity after completion of therapy) against vaccine-preventable diseases in children treated for various malignancies. Methods: Children and adolescents
ARTICLE IN PRESS
JVAC-15323; No. of Pages 5
Vaccine xxx (2014) xxx–xxx
Contents lists available at ScienceDirect
Vaccine journal homepage: www.elsevier.com/locate/vaccine
Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer Konrad Bochennek a , Regina Allwinn b,1 , Rebecca Langer a , Martina Becker a , Oliver T. Keppler b , Thomas Klingebiel a , Thomas Lehrnbecher a,∗ a b
Pediatric Hematology and Oncology, Children’s Hospital of the University of Frankfurt, Germany Institute of Medical Virology, University of Frankfurt, Germany
a r t i c l e
i n f o
Article history: Received 30 October 2013 Received in revised form 12 April 2014 Accepted 17 April 2014 Available online xxx Keywords: Vaccination Child Cancer Measles Mumps Rubella Varicella
a b s t r a c t Background: Intensive chemotherapy in children with cancer results in long-term impairment of humoral immunity. Whereas most studies to date focused on children with acute lymphoblastic leukemia (ALL), little data have been published on patients suffering from Hodgkin disease or from solid tumors. We therefore analyzed the loss of protective immunity (defined as immunity at the time of diagnosis and lack of immunity after completion of therapy) against vaccine-preventable diseases in children treated for various malignancies. Methods: Children and adolescents
