Accepted Manuscript Title: Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus Author: Ting Wang Meiye Wang Gehong Duan Xiao Chen Yanxia He PII: DOI: Reference:
S1201-9712(15)00136-8 http://dx.doi.org/doi:10.1016/j.ijid.2015.06.002 IJID 2354
To appear in:
International Journal of Infectious Diseases
Received date: Revised date: Accepted date:
1-5-2015 20-5-2015 4-6-2015
Please cite this article as: Wang T, Wang M, Duan G, Chen X, He Y, Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus, International Journal of Infectious Diseases (2015), http://dx.doi.org/10.1016/j.ijid.2015.06.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus Ting Wang a, Meiye Wang b, Gehong Duan a, Xiao Chen c, Yanxia He a,* a
cr
ip t
Medical Laboratory, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, China b Medical Laboratory, Children’s Hospital of Zhengzhou, 255 Gangdu Street, Zhengzho 450053, China c Medical Laboratory, Henan Provincial People’s Hospital, 7 Weiwu Road, Zhengzhou 450003, China
us
*Corresponding author. Tel.: +86-371-63974618, fax: +86-371-63934118 E-mail address: [email protected] (Yanxia He)
an
Abstract
Objectives: This study aims to elucidate the role of breastfeeding on vertical
M
transmission of HCMV and HBV and to investigate the difference in prenatal transmission via breast milk between HBV and HCMV. Methods: This detailed study monitored the kinetics of viral DNA load in maternal
d
milk for both HBV and HCMV, timely demonstrated the rate of transmission to
te
infants, and compared HBV infection rate with that of HCMV. Results: There was no difference in overall DNAlactia+ between HBV (23.86%) and
Ac ce p
HCMV (29.54%, P=0.140) for seropositive mothers, while HBsAg prevalence (0.75%) was significantly lower than HCMV IgG+ (27.44%, P
S1201-9712(15)00136-8 http://dx.doi.org/doi:10.1016/j.ijid.2015.06.002 IJID 2354
To appear in:
International Journal of Infectious Diseases
Received date: Revised date: Accepted date:
1-5-2015 20-5-2015 4-6-2015
Please cite this article as: Wang T, Wang M, Duan G, Chen X, He Y, Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus, International Journal of Infectious Diseases (2015), http://dx.doi.org/10.1016/j.ijid.2015.06.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus Ting Wang a, Meiye Wang b, Gehong Duan a, Xiao Chen c, Yanxia He a,* a
cr
ip t
Medical Laboratory, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, China b Medical Laboratory, Children’s Hospital of Zhengzhou, 255 Gangdu Street, Zhengzho 450053, China c Medical Laboratory, Henan Provincial People’s Hospital, 7 Weiwu Road, Zhengzhou 450003, China
us
*Corresponding author. Tel.: +86-371-63974618, fax: +86-371-63934118 E-mail address: [email protected] (Yanxia He)
an
Abstract
Objectives: This study aims to elucidate the role of breastfeeding on vertical
M
transmission of HCMV and HBV and to investigate the difference in prenatal transmission via breast milk between HBV and HCMV. Methods: This detailed study monitored the kinetics of viral DNA load in maternal
d
milk for both HBV and HCMV, timely demonstrated the rate of transmission to
te
infants, and compared HBV infection rate with that of HCMV. Results: There was no difference in overall DNAlactia+ between HBV (23.86%) and
Ac ce p
HCMV (29.54%, P=0.140) for seropositive mothers, while HBsAg prevalence (0.75%) was significantly lower than HCMV IgG+ (27.44%, P
