Sleep Breath DOI 10.1007/s11325-014-0942-8
ORIGINAL ARTICLE
DNA damage in peripheral blood lymphocytes from patients with OSAHS Jing Xie & Jianzhong Jiang & Keyun Shi & Tingting Zhang & Taofeng Zhu & Hong Chen & Ruhua Chen & Liming Qi & Weiliang Ding & Qiyi Yi & Tieliang Ma
Received: 24 June 2013 / Revised: 13 January 2014 / Accepted: 14 January 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by intermittent hypoxia during sleep time, followed by oxidative stress. Hypoxia-induced oxidative stress can lead to DNA damage, which is related to chromosome aberrations and micronuclei. The purpose of this study is to investigate the level of DNA damage in peripheral blood of patients with OSAHS. Methods Thirty patients with OSAHS diagnosed by polysomnography and 28 healthy volunteers were assessed by the Epworth sleepiness scale. The levels of DNA damage were investigated through the cytokinesis-blocked micronucleus assay. Results In the group of patients with OSAHS, the mean frequency of binucleated cells with micronuclei were significantly higher than that in the control group (P
ORIGINAL ARTICLE
DNA damage in peripheral blood lymphocytes from patients with OSAHS Jing Xie & Jianzhong Jiang & Keyun Shi & Tingting Zhang & Taofeng Zhu & Hong Chen & Ruhua Chen & Liming Qi & Weiliang Ding & Qiyi Yi & Tieliang Ma
Received: 24 June 2013 / Revised: 13 January 2014 / Accepted: 14 January 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by intermittent hypoxia during sleep time, followed by oxidative stress. Hypoxia-induced oxidative stress can lead to DNA damage, which is related to chromosome aberrations and micronuclei. The purpose of this study is to investigate the level of DNA damage in peripheral blood of patients with OSAHS. Methods Thirty patients with OSAHS diagnosed by polysomnography and 28 healthy volunteers were assessed by the Epworth sleepiness scale. The levels of DNA damage were investigated through the cytokinesis-blocked micronucleus assay. Results In the group of patients with OSAHS, the mean frequency of binucleated cells with micronuclei were significantly higher than that in the control group (P
