686 TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (1992) 86, 686-692
Does antibody dissemination
to mycobacterial antigens, in childhood tuberculosis?
including
lipoarabinomannan,
limit
A. M. de L. Costello3, A. Kumar’, V. Narayan’, M. S. Akbar2, S. Ahmed2, C. Abou-Zeid4, G. A. W. Rook4, J. lDepartment of Child Health, Niloufw Hospital, Hyderabad, Bangladesh; 2Bangladesh Stanford4 and C. Moreno Institute of Child Health, Dhaka, Bangladesh; 3Departments of Paediatrics and 4Medical Microbiology, University College and Middlesex School of Medicine, London, UK; sMRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK Abstract
Serum immunoglobulin (Ig) G responsesto a variety of mycobacterial antigens were measured in children from the UK, in children with tuberculosis from Hyderabad, India and Dhaka, Bangladesh, classified according to whether the diseasewas disseminated or localized, and in non-tuberculous controls. Anti-lipoarabinomannan (LAM) IgG responsesin UK children showed a marked trough between 6 months and 3 years coincident with the reported peak incidence of disseminated tuberculosts. Geometric mean IgG responsesto sonicatesof slow-growing mycobacteria (rich in LAM) in 36 children with disseminated tuberculosis were markedly lower than in 99 children with localized tuberculous lesions (for Mycobacterium scrofulaceum PCO.01, for M. tuberculosis PCO.01, and for M. vaccae PtO.O1). Responsesto purified LAM were also lower in the disseminated tuberculosis eroun (P
Does antibody dissemination
to mycobacterial antigens, in childhood tuberculosis?
including
lipoarabinomannan,
limit
A. M. de L. Costello3, A. Kumar’, V. Narayan’, M. S. Akbar2, S. Ahmed2, C. Abou-Zeid4, G. A. W. Rook4, J. lDepartment of Child Health, Niloufw Hospital, Hyderabad, Bangladesh; 2Bangladesh Stanford4 and C. Moreno Institute of Child Health, Dhaka, Bangladesh; 3Departments of Paediatrics and 4Medical Microbiology, University College and Middlesex School of Medicine, London, UK; sMRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK Abstract
Serum immunoglobulin (Ig) G responsesto a variety of mycobacterial antigens were measured in children from the UK, in children with tuberculosis from Hyderabad, India and Dhaka, Bangladesh, classified according to whether the diseasewas disseminated or localized, and in non-tuberculous controls. Anti-lipoarabinomannan (LAM) IgG responsesin UK children showed a marked trough between 6 months and 3 years coincident with the reported peak incidence of disseminated tuberculosts. Geometric mean IgG responsesto sonicatesof slow-growing mycobacteria (rich in LAM) in 36 children with disseminated tuberculosis were markedly lower than in 99 children with localized tuberculous lesions (for Mycobacterium scrofulaceum PCO.01, for M. tuberculosis PCO.01, and for M. vaccae PtO.O1). Responsesto purified LAM were also lower in the disseminated tuberculosis eroun (P
