BEST EVIDENCE TOPIC – ADULT CARDIAC
Interactive CardioVascular and Thoracic Surgery 20 (2015) 422–428 doi:10.1093/icvts/ivu402 Advance Access publication 4 December 2014
Does preoperative statin therapy prevent postoperative atrial fibrillation in patients undergoing cardiac surgery? Sean L. Goha,*, Kok H. Yapb, Kim C. Chuab and Victor T.T. Chaob a b
Royal Prince Alfred Hospital, Sydney, NSW, Australia Department of Cardiothoracic Surgery, National Heart Centre, Singapore General Hospital, Singapore
* Corresponding author. Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia. Tel: +61-240-3548684; e-mail: [email protected] (S.L. Goh). Received 20 May 2014; received in revised form 6 November 2014; accepted 11 November 2014
Abstract A best evidence topic was written according to a structured protocol. The question addressed was: does preoperative statin therapy prevent postoperative atrial fibrillation (AF) in patients undergoing cardiac surgery? There were 445 papers found using the reported search. From these, 12 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. This paper includes three systematic reviews with meta-analysis, five randomized controlled trials and four retrospective studies. All the papers compared either all or some of the following postoperative complications: mortality, morbidity, AF, length of hospital stay (intensive care unit and hospital) and inflammatory markers. The largest study in this paper includes a systematic review of 91 491 patients that showed a reduction in postoperative AF with preoperative statin therapy (OR = 0.71, 95% CI 0.61–0.82, P
Interactive CardioVascular and Thoracic Surgery 20 (2015) 422–428 doi:10.1093/icvts/ivu402 Advance Access publication 4 December 2014
Does preoperative statin therapy prevent postoperative atrial fibrillation in patients undergoing cardiac surgery? Sean L. Goha,*, Kok H. Yapb, Kim C. Chuab and Victor T.T. Chaob a b
Royal Prince Alfred Hospital, Sydney, NSW, Australia Department of Cardiothoracic Surgery, National Heart Centre, Singapore General Hospital, Singapore
* Corresponding author. Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia. Tel: +61-240-3548684; e-mail: [email protected] (S.L. Goh). Received 20 May 2014; received in revised form 6 November 2014; accepted 11 November 2014
Abstract A best evidence topic was written according to a structured protocol. The question addressed was: does preoperative statin therapy prevent postoperative atrial fibrillation (AF) in patients undergoing cardiac surgery? There were 445 papers found using the reported search. From these, 12 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. This paper includes three systematic reviews with meta-analysis, five randomized controlled trials and four retrospective studies. All the papers compared either all or some of the following postoperative complications: mortality, morbidity, AF, length of hospital stay (intensive care unit and hospital) and inflammatory markers. The largest study in this paper includes a systematic review of 91 491 patients that showed a reduction in postoperative AF with preoperative statin therapy (OR = 0.71, 95% CI 0.61–0.82, P
