Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke?: Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Svetlana Lorenzano, Niaz Ahmed, Anne Falcou, Robert Mikulik, Turgut Tatlisumak, Christine Roffe, Nils Wahlgren and Danilo Toni Stroke. published online October 30, 2013; Stroke is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2013 American Heart Association, Inc. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://stroke.ahajournals.org/content/early/2013/10/29/STROKEAHA.113.002908
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Original Contribution Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Svetlana Lorenzano, MD, PhD, MSc; Niaz Ahmed, MD, PhD; Anne Falcou, MD, PhD; Robert Mikulik, MD, PhD; Turgut Tatlisumak, MD, PhD; Christine Roffe, MD; Nils Wahlgren, MD, PhD; Danilo Toni, MD, PhD, FESO; on behalf of the SITS Investigators Background and Purpose—Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator–treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. Methods—A total of 45 079 patients treated with intravenous alteplase were recorded from 2002 to 2011. Main outcome measures were symptomatic intracerebral hemorrhage, functional independence (modified Rankin Scale score, 0–2), and mortality at 3 months. Results—Among 25 777 (57.2%) men and 19 302 (42.8%) women, we found no difference in the rate of symptomatic intracerebral hemorrhage (P=0.13), a significantly higher likelihood of functional independence at 3 months in men (P
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://stroke.ahajournals.org/content/early/2013/10/29/STROKEAHA.113.002908
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Stroke can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Stroke is online at: http://stroke.ahajournals.org//subscriptions/
Downloaded from http://stroke.ahajournals.org/ at BOSTON UNIV MED LIBR on November 3, 2013
Original Contribution Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Svetlana Lorenzano, MD, PhD, MSc; Niaz Ahmed, MD, PhD; Anne Falcou, MD, PhD; Robert Mikulik, MD, PhD; Turgut Tatlisumak, MD, PhD; Christine Roffe, MD; Nils Wahlgren, MD, PhD; Danilo Toni, MD, PhD, FESO; on behalf of the SITS Investigators Background and Purpose—Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator–treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. Methods—A total of 45 079 patients treated with intravenous alteplase were recorded from 2002 to 2011. Main outcome measures were symptomatic intracerebral hemorrhage, functional independence (modified Rankin Scale score, 0–2), and mortality at 3 months. Results—Among 25 777 (57.2%) men and 19 302 (42.8%) women, we found no difference in the rate of symptomatic intracerebral hemorrhage (P=0.13), a significantly higher likelihood of functional independence at 3 months in men (P
