Clin Rheumatol (2014) 33:763–767 DOI 10.1007/s10067-014-2664-5
ORIGINAL ARTICLE
Does the microbiome play a causal role in spondyloarthritis? James T. Rosenbaum & Phoebe Lin & Mark Asquith & Mary-Ellen Costello & Tony J. Kenna & Matthew A. Brown
Received: 31 January 2014 / Accepted: 24 March 2014 / Published online: 10 May 2014 # Clinical Rheumatology 2014
Abstract The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged. Keywords Inflammatory bowel disease . Microbiome . Spondyloarthritis The microbiome is a term coined by the Nobel Laureate Joshua Lederberg to describe the collection of microorganisms that
J. T. Rosenbaum (*) : P. Lin : M. Asquith Division of Arthritis and Rheumatic Diseases and Department of Ophthalmology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd. L467Ad, Portland, OR 97239, USA e-mail: [email protected] J. T. Rosenbaum Legacy Devers Eye Institute, 1040 NW 22nd Ave, Portland, OR 97210, USA M.
ORIGINAL ARTICLE
Does the microbiome play a causal role in spondyloarthritis? James T. Rosenbaum & Phoebe Lin & Mark Asquith & Mary-Ellen Costello & Tony J. Kenna & Matthew A. Brown
Received: 31 January 2014 / Accepted: 24 March 2014 / Published online: 10 May 2014 # Clinical Rheumatology 2014
Abstract The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged. Keywords Inflammatory bowel disease . Microbiome . Spondyloarthritis The microbiome is a term coined by the Nobel Laureate Joshua Lederberg to describe the collection of microorganisms that
J. T. Rosenbaum (*) : P. Lin : M. Asquith Division of Arthritis and Rheumatic Diseases and Department of Ophthalmology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd. L467Ad, Portland, OR 97239, USA e-mail: [email protected] J. T. Rosenbaum Legacy Devers Eye Institute, 1040 NW 22nd Ave, Portland, OR 97210, USA M.
