Di Pentima et al. Antimicrobial Resistance and Infection Control 2014, 3:29 http://www.aricjournal.com/content/3/1/29
RESEARCH
Open Access
Driving forces of vancomycin-resistant E. faecium and E. faecalis blood-stream infections in children Maria Cecilia Di Pentima1*, Shannon Chan2, Carol Briody3†, Michelle Power3† and Jobayer Hossain4,5†
Abstract Background: Rates of invasive vancomycin-resistant Enterococcus (VRE) in the USA remains on the rise. Efforts to control vancomycin use and nosocomial transmission have had limited success in halting the spread of this pathogen. The role of antibiotic exposure remains a topic of controversy. We evaluated the association between emergence of VRE-blood-stream infections (BSI), aggregate and individual-patient vancomycin- exposure, and clonal transmission of VRE at an academic pediatric tertiary care hospital. Methods: E. faecium and E. faecalis isolates recovered from blood specimens from hospitalized children from 2003–2010 were retrieved from the microbiology database. Aggregate vancomycin use and individual-patient vancomycin exposure 6 months preceding each event of bacteremia were recorded. Pulse-field electrophoresis was performed on selected VRE isolates. Results: Of 151 episodes of E. faecium and E. faecalis BSI among hospitalized children
RESEARCH
Open Access
Driving forces of vancomycin-resistant E. faecium and E. faecalis blood-stream infections in children Maria Cecilia Di Pentima1*, Shannon Chan2, Carol Briody3†, Michelle Power3† and Jobayer Hossain4,5†
Abstract Background: Rates of invasive vancomycin-resistant Enterococcus (VRE) in the USA remains on the rise. Efforts to control vancomycin use and nosocomial transmission have had limited success in halting the spread of this pathogen. The role of antibiotic exposure remains a topic of controversy. We evaluated the association between emergence of VRE-blood-stream infections (BSI), aggregate and individual-patient vancomycin- exposure, and clonal transmission of VRE at an academic pediatric tertiary care hospital. Methods: E. faecium and E. faecalis isolates recovered from blood specimens from hospitalized children from 2003–2010 were retrieved from the microbiology database. Aggregate vancomycin use and individual-patient vancomycin exposure 6 months preceding each event of bacteremia were recorded. Pulse-field electrophoresis was performed on selected VRE isolates. Results: Of 151 episodes of E. faecium and E. faecalis BSI among hospitalized children
