Asian Pacific Journal of Tropical Medicine (2014)285-288

285

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Asian Pacific Journal of Tropical Medicine journal homepage:www.elsevier.com/locate/apjtm

Document heading

doi: 10.1016/S1995-7645(14)60039-0

Dynamic Wnt5a expression in murine hair follicle cycle and its inhibitory effects on follicular in vivo De-Ren Fang1*, Zhong-Fa Lv2, Gang Qiao3 Department of Dermatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China Department of Dermatology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China 3 Department of Dermatology, the Third People’s Hospital of Hanghzhou, Hanghzhou, 310009 China 1 2

ARTICLE INFO

ABSTRACT

Article history: Received 10 December 2013 Received in revised form 15 January 2014 Accepted 15 March 2014 Available online 20 April 2014

Objective: To analyze the dynamic expression of Wnt family member 5A (Wingless-type MMTV integration Wnt site family, member 5a) in murine hair cycle and its inhibitory effects on follicle in vivo. Methods: Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages, and Ad-Wnt5a was injected after defeathering to observe the hair follicle growth in vivo. Results: The Wnt5a mRNA was expressed at birth, and was firstly increased then decreased along with the progress of the hair cycle. It reached the peak in advanced stage of growth cycle (P

Dynamic Wnt5a expression in murine hair follicle cycle and its inhibitory effects on follicular.

To analyze the dynamic expression of Wnt family member 5A (Wingless-type MMTV integration Wnt site family, member 5a) in murine hair cycle and its inh...
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