HHS Public Access Author manuscript Author Manuscript
J Pediatr. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: J Pediatr. 2016 October ; 177: 97–102.e2. doi:10.1016/j.jpeds.2016.06.079.
Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns
Author Manuscript
Katherine C. Wai, BS1, Michael A. Kohn, MD, MPP2, Roberta A. Ballard, MD3, William E. Truog, MD4, Dennis M. Black, PhD2, Jeanette M. Asselin, MS, RTT-NPS5, Philip L. Ballard, MD, PhD3, Elizabeth E. Rogers, MD3, and Roberta L. Keller, MD3,* on behalf of the Trial of Late Surfactant (TOLSURF) Study Group 1School
of Medicine, University of California San Francisco
2Department
of Epidemiology and Biostatistics, University of California San Francisco
3Department
of Pediatrics, UCSF Benioff Children’s hospital, San Francisco, CA
4Department
of Pediatrics, Children’s Mercy Hospital, Kansas City, MO
5Department
of Pediatrics, UCSF Benioff Children’s Hospital Oakland, Oakland, CA
Abstract Author Manuscript
Objective—To assess the prognostic accuracy of early cumulative supplemental oxygen (CSO) exposure for prediction of BPD or death and to evaluate the independent association of CSO with BPD or death Study design—We performed a secondary analysis of the Trial of Late Surfactant, which enrolled 511 infants ≤28 weeks' gestational age who were mechanically ventilated at 7–14 days. Our primary outcome was BPD or death at 36 weeks' post-menstrual age, determined by physiologic oxygen/flow challenge. Average daily supplemental oxygen (FiO2−0.21) was calculated. CSO was calculated as the sum of the average daily supplemental oxygen over time periods of interest up to 28 days of age. We generated area under the receiver-operating-curve (AUROC) to evaluate the accuracy of CSO for prediction of BPD or death. We assessed the independent relationship between CSO and BPD or death in multivariate modeling, while adjusting for mean airway pressure.
Author Manuscript
Results—Infants were 25.2±1.2 weeks and 700±165g at birth. At 14 days, AUROC for CSO (0.70, 0.65–0.74) was significantly better than CSO at earlier time points for outcome prediction; it did not increase with addition of later data. In multivariate modeling, an increase of 1 in CSO at
Corresponding Author: Roberta L. Keller, Contact: [email protected] | 550 16th St, Box: 0734, San Francisco, CA 94158 | 415-476-1888. *List of additional members of TOLSURF Study Group is available at www.jpeds.com (Appendix). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The authors declare no conflicts of interest.
Wai et al.
Page 2
Author Manuscript
14 days increased the odds of BPD or death (OR=1.7, 1.3–2.2; p
J Pediatr. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: J Pediatr. 2016 October ; 177: 97–102.e2. doi:10.1016/j.jpeds.2016.06.079.
Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns
Author Manuscript
Katherine C. Wai, BS1, Michael A. Kohn, MD, MPP2, Roberta A. Ballard, MD3, William E. Truog, MD4, Dennis M. Black, PhD2, Jeanette M. Asselin, MS, RTT-NPS5, Philip L. Ballard, MD, PhD3, Elizabeth E. Rogers, MD3, and Roberta L. Keller, MD3,* on behalf of the Trial of Late Surfactant (TOLSURF) Study Group 1School
of Medicine, University of California San Francisco
2Department
of Epidemiology and Biostatistics, University of California San Francisco
3Department
of Pediatrics, UCSF Benioff Children’s hospital, San Francisco, CA
4Department
of Pediatrics, Children’s Mercy Hospital, Kansas City, MO
5Department
of Pediatrics, UCSF Benioff Children’s Hospital Oakland, Oakland, CA
Abstract Author Manuscript
Objective—To assess the prognostic accuracy of early cumulative supplemental oxygen (CSO) exposure for prediction of BPD or death and to evaluate the independent association of CSO with BPD or death Study design—We performed a secondary analysis of the Trial of Late Surfactant, which enrolled 511 infants ≤28 weeks' gestational age who were mechanically ventilated at 7–14 days. Our primary outcome was BPD or death at 36 weeks' post-menstrual age, determined by physiologic oxygen/flow challenge. Average daily supplemental oxygen (FiO2−0.21) was calculated. CSO was calculated as the sum of the average daily supplemental oxygen over time periods of interest up to 28 days of age. We generated area under the receiver-operating-curve (AUROC) to evaluate the accuracy of CSO for prediction of BPD or death. We assessed the independent relationship between CSO and BPD or death in multivariate modeling, while adjusting for mean airway pressure.
Author Manuscript
Results—Infants were 25.2±1.2 weeks and 700±165g at birth. At 14 days, AUROC for CSO (0.70, 0.65–0.74) was significantly better than CSO at earlier time points for outcome prediction; it did not increase with addition of later data. In multivariate modeling, an increase of 1 in CSO at
Corresponding Author: Roberta L. Keller, Contact: [email protected] | 550 16th St, Box: 0734, San Francisco, CA 94158 | 415-476-1888. *List of additional members of TOLSURF Study Group is available at www.jpeds.com (Appendix). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The authors declare no conflicts of interest.
Wai et al.
Page 2
Author Manuscript
14 days increased the odds of BPD or death (OR=1.7, 1.3–2.2; p
