Fetal and Pediatric Pathology
ISSN: 1551-3815 (Print) 1551-3823 (Online) Journal homepage: http://www.tandfonline.com/loi/ipdp20
Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu & Amanjit Bal To cite this article: Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu & Amanjit Bal (2016) Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases, Fetal and Pediatric Pathology, 35:2, 98-103, DOI: 10.3109/15513815.2015.1135495 To link to this article: http://dx.doi.org/10.3109/15513815.2015.1135495
Published online: 16 Feb 2016.
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Date: 15 April 2016, At: 10:54
FETAL AND PEDIATRIC PATHOLOGY , VOL. , NO. , – http://dx.doi.org/./..
Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu, and Amanjit Bal
Downloaded by [Gazi University] at 10:54 15 April 2016
Department of Histopathology, PGIMER, Chandigarh, India
ABSTRACT
ARTICLE HISTORY
Ectopic immature renal tissue (EIRT) is a lesion rarely described in the literature. It shows the components of a nephrogenic rest including the blastema, epithelia, and stroma. We report two cases of EIRT in a 3-year-old female and an 8 months male child, associated with lipomeningomyelocele and an enteric duplication cyst, respectively, along with detailed immunohistochemical profile. Though there are a few cases of EIRT associated with teratoma, only two cases of EIRT associated with lipomeningomyelocele have been described in the English literature. Moreover, extensive literature search did not reveal any previous case report where EIRT had been documented in an enteric duplication cyst.
Received December Revised December Accepted December KEYWORDS
EIRT; lipomeningomyelocele; enteric duplication cyst
Introduction Ectopic immature renal tissue (EIRT) is a metanephric nephrogenic rest found at an extrarenal site. EIRT is also known by other terminologies like ectopic, heterotopic or extrarenal nephrogenic rest or extrarenal nephroblastomatosis, all of which are appropriate [1, 2]. EIRTs are rarely reported in the literature and majority of the reported cases are associated with teratoma whereas in others it occurred as an isolated mass or within a lipomeningomyelocele. EIRT has diagnostic significance whether occurring with teratoma or lipomeningomyelocele or in isolation as rarely it can give rise to extrarenal Wilm’s tumor. Moreover, when it occurs singly it can be potentially mistaken as Wilm’s tumor. We report two cases of EIRT, one of which was found incidentally in a lipomeningomyelocele and the other being associated with an enteric duplication cyst. It is to be noted in this context that the presence of EIRT in association with a lipomeningomyelocele and an enteric duplication cyst is an extremely rare phenomenon, especially so in the duplication cyst where it has not been previously described to the best of our knowledge.
Case reports Case 1 A 3-year-old female child presented with a swelling over the lower back (lumbar region) since birth which gradually increased in size to the present size of 5.5 × 3 × 2 cm. There was no CONTACT Amanjit Bal [email protected] Department of Histopathology, PGIMER, Chandigarh , India. Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ipdp. © Taylor & Francis Group, LLC
Downloaded by [Gazi University] at 10:54 15 April 2016
FETAL AND PEDIATRIC PATHOLOGY
99
Figure . (Case ) a: MRI shows the presence of lipomenigomyelocele without the presence of spina bifida; no heterotopic tooth or bone formation was seen to suggest a posssibility of a teratoma; b: The nodular lesion shows multiple immature glomeruli and tubules along with intervening glial tissue (H&E, ×), c: Immunohistochemistry for GFAP stain highlights glial tissue (GFAP immunostain, ×), d: Ki index is low
ISSN: 1551-3815 (Print) 1551-3823 (Online) Journal homepage: http://www.tandfonline.com/loi/ipdp20
Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu & Amanjit Bal To cite this article: Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu & Amanjit Bal (2016) Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases, Fetal and Pediatric Pathology, 35:2, 98-103, DOI: 10.3109/15513815.2015.1135495 To link to this article: http://dx.doi.org/10.3109/15513815.2015.1135495
Published online: 16 Feb 2016.
Submit your article to this journal
Article views: 5
View related articles
View Crossmark data
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ipdp20 Download by: [Gazi University]
Date: 15 April 2016, At: 10:54
FETAL AND PEDIATRIC PATHOLOGY , VOL. , NO. , – http://dx.doi.org/./..
Ectopic Immature Renal Tissue Associated with Lipomeningomyelocele and Enteric Duplication Cyst: A Report of Two Cases Suvradeep Mitra, Navneet Singla, Gurpreet Singh Sandhu, and Amanjit Bal
Downloaded by [Gazi University] at 10:54 15 April 2016
Department of Histopathology, PGIMER, Chandigarh, India
ABSTRACT
ARTICLE HISTORY
Ectopic immature renal tissue (EIRT) is a lesion rarely described in the literature. It shows the components of a nephrogenic rest including the blastema, epithelia, and stroma. We report two cases of EIRT in a 3-year-old female and an 8 months male child, associated with lipomeningomyelocele and an enteric duplication cyst, respectively, along with detailed immunohistochemical profile. Though there are a few cases of EIRT associated with teratoma, only two cases of EIRT associated with lipomeningomyelocele have been described in the English literature. Moreover, extensive literature search did not reveal any previous case report where EIRT had been documented in an enteric duplication cyst.
Received December Revised December Accepted December KEYWORDS
EIRT; lipomeningomyelocele; enteric duplication cyst
Introduction Ectopic immature renal tissue (EIRT) is a metanephric nephrogenic rest found at an extrarenal site. EIRT is also known by other terminologies like ectopic, heterotopic or extrarenal nephrogenic rest or extrarenal nephroblastomatosis, all of which are appropriate [1, 2]. EIRTs are rarely reported in the literature and majority of the reported cases are associated with teratoma whereas in others it occurred as an isolated mass or within a lipomeningomyelocele. EIRT has diagnostic significance whether occurring with teratoma or lipomeningomyelocele or in isolation as rarely it can give rise to extrarenal Wilm’s tumor. Moreover, when it occurs singly it can be potentially mistaken as Wilm’s tumor. We report two cases of EIRT, one of which was found incidentally in a lipomeningomyelocele and the other being associated with an enteric duplication cyst. It is to be noted in this context that the presence of EIRT in association with a lipomeningomyelocele and an enteric duplication cyst is an extremely rare phenomenon, especially so in the duplication cyst where it has not been previously described to the best of our knowledge.
Case reports Case 1 A 3-year-old female child presented with a swelling over the lower back (lumbar region) since birth which gradually increased in size to the present size of 5.5 × 3 × 2 cm. There was no CONTACT Amanjit Bal [email protected] Department of Histopathology, PGIMER, Chandigarh , India. Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ipdp. © Taylor & Francis Group, LLC
Downloaded by [Gazi University] at 10:54 15 April 2016
FETAL AND PEDIATRIC PATHOLOGY
99
Figure . (Case ) a: MRI shows the presence of lipomenigomyelocele without the presence of spina bifida; no heterotopic tooth or bone formation was seen to suggest a posssibility of a teratoma; b: The nodular lesion shows multiple immature glomeruli and tubules along with intervening glial tissue (H&E, ×), c: Immunohistochemistry for GFAP stain highlights glial tissue (GFAP immunostain, ×), d: Ki index is low
