Editorial Commentary: ACL Bioactive Scaffold
Abstract: ACL bioactive scaffolds may be used to bioenhance ACL primary repair, and they show preclinical (porcine) promise. We are extremely interested in ongoing clinical development.
See related article on page 990
E
arlier in the ISAKOS Knee Biologics Supplement Part II, we commented that we admire Martha Murray and her colleagues’ use of a bioactive scaffold in a porcine model.1,2 Closer study of their article “Bioenhanced repair of the anterior cruciate ligament” by Proffen, Sieker, and Murray3 reveals a fine distinction. Rather than tissue engineer an entire ACL, Murray and her research colleagues from Boston Children’s Hospital, use their scaffold to augment ACL primary suture repair with a goal of “bioenhancing” host ACL healing. It makes intuitive sense that this strategy might be most successful in pediatric or adolescent patients. In Arthroscopy, we usually prefer articles with short introductions,4,5 but the authors’ history of ACL primary repair is definitely worth savoring. Each section of the article leads logically to the next, totally makes sense, and the preclinical data in a large animal model is amazing with regard to both ACL healing and osteoarthritis preventiondthe holy grail. We are now obligated, and invite readers to join us, to boldly lobby Dr. Murray and her colleagues to please thoughtfully consider submission of their “FDA approved.human clinical.study” to Arthroscopy. We are extremely interested in clinical developments.
James H. Lubowitz, M.D. Editor-in-Chief
References 1. Hogan MV, Kawakami Y, Murawski CD, Fu FH. Tissue engineering of ligaments for reconstructive surgery. Arthroscopy 2015;31:971-979. 2. Lubowitz JH. Editorial commentary: ACL Tissue bioengineering clinical application is in its infancy. Arthroscopy 2015;31:980. 3. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy 2015;31: 990-997. 4. Lubowitz JH, Poehling GG, Karlsson J. How to write a scientific article: A painless guide to putting it all together. In: Karlsson J, Marx R, Nakamura N, Bhandari M, eds. ISAKOS Scientific Committee Research Methods Handbook. A practical guide to research: Design, execution, and publication. Arthroscopy 2011;27:S97-S102 (suppl 2). 5. Karlsson J, Lubowitz JH, Poehling GG. Common mistakes in manuscripts and how to avoid them. In: Karlsson J, Marx R, Nakamura N, Bhandari M, eds. ISAKOS Scientific Committee Research Methods Handbook. A practical guide to research: Design, execution, and publication. Arthroscopy 2011;27:S102-S104 (suppl 2).
Ó 2015 by the Arthroscopy Association of North America 0749-8063/15196/$36.00 http://dx.doi.org/10.1016/j.arthro.2015.02.041
998
Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 31, No 5 (May), 2015: p 998
Abstract: ACL bioactive scaffolds may be used to bioenhance ACL primary repair, and they show preclinical (porcine) promise. We are extremely interested in ongoing clinical development.
See related article on page 990
E
arlier in the ISAKOS Knee Biologics Supplement Part II, we commented that we admire Martha Murray and her colleagues’ use of a bioactive scaffold in a porcine model.1,2 Closer study of their article “Bioenhanced repair of the anterior cruciate ligament” by Proffen, Sieker, and Murray3 reveals a fine distinction. Rather than tissue engineer an entire ACL, Murray and her research colleagues from Boston Children’s Hospital, use their scaffold to augment ACL primary suture repair with a goal of “bioenhancing” host ACL healing. It makes intuitive sense that this strategy might be most successful in pediatric or adolescent patients. In Arthroscopy, we usually prefer articles with short introductions,4,5 but the authors’ history of ACL primary repair is definitely worth savoring. Each section of the article leads logically to the next, totally makes sense, and the preclinical data in a large animal model is amazing with regard to both ACL healing and osteoarthritis preventiondthe holy grail. We are now obligated, and invite readers to join us, to boldly lobby Dr. Murray and her colleagues to please thoughtfully consider submission of their “FDA approved.human clinical.study” to Arthroscopy. We are extremely interested in clinical developments.
James H. Lubowitz, M.D. Editor-in-Chief
References 1. Hogan MV, Kawakami Y, Murawski CD, Fu FH. Tissue engineering of ligaments for reconstructive surgery. Arthroscopy 2015;31:971-979. 2. Lubowitz JH. Editorial commentary: ACL Tissue bioengineering clinical application is in its infancy. Arthroscopy 2015;31:980. 3. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy 2015;31: 990-997. 4. Lubowitz JH, Poehling GG, Karlsson J. How to write a scientific article: A painless guide to putting it all together. In: Karlsson J, Marx R, Nakamura N, Bhandari M, eds. ISAKOS Scientific Committee Research Methods Handbook. A practical guide to research: Design, execution, and publication. Arthroscopy 2011;27:S97-S102 (suppl 2). 5. Karlsson J, Lubowitz JH, Poehling GG. Common mistakes in manuscripts and how to avoid them. In: Karlsson J, Marx R, Nakamura N, Bhandari M, eds. ISAKOS Scientific Committee Research Methods Handbook. A practical guide to research: Design, execution, and publication. Arthroscopy 2011;27:S102-S104 (suppl 2).
Ó 2015 by the Arthroscopy Association of North America 0749-8063/15196/$36.00 http://dx.doi.org/10.1016/j.arthro.2015.02.041
998
Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 31, No 5 (May), 2015: p 998
